@article{3076379,
    title = "The effect of antioxidant and anti-inflammatory capacity of diet on psoriasis and psoriatic arthritis phenotype: Nutrition as therapeutic tool?",
    author = "Katsimbri, P. and Korakas, E. and Kountouri, A. and Ikonomidis, I. and Tsougos, E. and Vlachos, D. and Papadavid, E. and Raptis, A. and Lambadiari, V.",
    journal = "Free Radicals and Antioxidants",
    year = "2021",
    volume = "10",
    number = "2",
    pages = "1-28",
    publisher = "MDPI",
    issn = "2231-2536",
    doi = "10.3390/antiox10020157",
    abstract = "Chronic inflammation and increased oxidative stress are contributing factors to many non-communicable diseases. A growing body of evidence indicates that dietary nutrients can activate the immune system and may lead to the overproduction of pro-inflammatory cytokines. Fatty acids as macronutrients are key players for immunomodulation, with n-3 polyunsaturated fatty acids having the most beneficial effect, while polyphenols and carotenoids seem to be the most promising antioxidants. Psoriasis is a chronic, immune-mediated inflammatory disease with multifactorial etiology. Obesity is a major risk factor for psoriasis, which leads to worse clinical outcomes. Weight loss interventions and, generally, dietary regimens such as gluten-free and Mediterranean diet or supplement use may potentially improve psoriasis’ natural course and response to therapy. However, data about more sophisticated nutritional patterns, such as ketogenic, very low-carb or specific macro-and micro-nutrient substitution, are scarce. This review aims to present the effect of strictly structured dietary nutrients, that are known to affect glucose/lipid metabolism and insulin responses, on chronic inflammation and immunity, and to discuss the utility of nutritional regimens as possible therapeutic tools for psoriasis and psoriatic arthritis. © 2021 by the authors. Licensee MDPI, Basel, Switzerland."
}