@article{3076535,
    title = "Clinical management of patients with genetic obesity during COVID-19 pandemic: position paper of the ESE Growth & Genetic Obesity COVID-19 Study Group and Rare Endo-ERN main thematic group on Growth and Obesity",
    author = "De Groot, C.J. and Poitou Bernert, C. and Coupaye, M. and Clement, K. and Paschou, S.A. and Charmandari, E. and Kanaka-Gantenbein, C. and Wabitsch, M. and Buddingh, E.P. and Nieuwenhuijsen, B. and Marina, L. and Johannsson, G. and Van Den Akker, E.L.T.",
    journal = "Endocrine Development",
    year = "2021",
    volume = "71",
    number = "3",
    pages = "653-662",
    publisher = "Springer-Verlag",
    doi = "10.1007/s12020-021-02619-y",
    keywords = "adrenal insufficiency;  body size;  coronavirus disease 2019;  disease severity;  genetic obesity;  high risk population;  human;  infection risk;  obesity;  pandemic;  patient care;  phenotype;  priority journal;  quarantine;  Review;  risk assessment;  anxiety;  disease management;  genetics;  healthy lifestyle;  obesity, Anxiety;  COVID-19;  Disease Management;  Healthy Lifestyle;  Humans;  Obesity;  Pandemics",
    abstract = "This article aims to provide guidance on prevention and treatment of COVID-19 in patients with genetic obesity. Key principals of the management of patients with genetic obesity during COVID-19 pandemic for patients that have contracted COVID-19 are to be aware of: possible adrenal insufficiency (e.g., POMC deficiency, PWS); a more severe course in patients with concomitant immunodeficiency (e.g., LEP and LEPR deficiency), although defective leptin signalling could also be protective against the pro-inflammatory phenotype of COVID-19; disease severity being masked by insufficient awareness of symptoms in syndromic obesity patients with intellectual deficit (in particular PWS); to adjust medication dose to increased body size, preferably use dosing in m2; the high risk of malnutrition in patients with Sars-Cov2 infection, even in case of obesity. Key principals of the obesity management during the pandemic are to strive for optimal obesity management and a healthy lifestyle within the possibilities of the regulations to prevent weight (re)gain and to address anxiety within consultations, since prevalence of anxiety for COVID-19 is underestimated. © 2021, The Author(s)."
}