@article{3076652,
    title = "Clinical significance of histone deacetylase (Hdac)-1,-2,-4 and-6 expression in salivary gland tumors",
    author = "Pouloudi, D. and Manou, M. and Sarantis, P. and Tsoukalas, N. and Tsourouflis, G. and Dana, E. and Karamouzis, M.V. and Klijanienko, J. and Theocharis, S.",
    journal = "DIAGNOSTIC ONCOLOGY",
    year = "2021",
    volume = "11",
    number = "3",
    publisher = "MDPI",
    doi = "10.3390/diagnostics11030517",
    keywords = "biological marker;  histone deacetylase 1;  histone deacetylase 2;  histone deacetylase 4;  histone deacetylase 6, acinar cell carcinoma;  adenocarcinoma;  adenoid cystic carcinoma;  adenoma;  adult;  aged;  Article;  basal cell carcinoma;  cancer prognosis;  cancer survival;  controlled study;  epithelial myoepithelial carcinoma;  female;  human;  human tissue;  immunohistochemistry;  major clinical study;  male;  mouth squamous cell carcinoma;  mucoepidermoid tumor;  overall survival;  pleomorphic adenoma;  protein expression;  salivary duct carcinoma;  salivary gland tumor;  survival rate;  Warthin tumor",
    abstract = "Salivary gland tumors (SGTs) comprise a group of rare neoplasms. Locally aggressive, recurrent and/or metastatic SGTs are notorious for their resistance to systemic therapy, making the need for carefully designed, prospective and randomized trials with useful predictive markers mandatory to define new effective therapeutic protocols. Histone Deacetylases (HDACs), are thought to play a crucial role in carcinogenesis. They affect the DNA structure, being also able to regulate its transcription, repair, and replication. This study aimed to evaluate—to our knowledge for the first time—the HDAC-1,-2,-4 and-6 immunohistochemical expression in SGTs and their potential use as prognostic biomarkers. Medical records and archival histopathological material of 58 (36 benign and 22 malignant) SGT patients were included in this study. The H-score was statistically correlated with the clinicopathological characteristics for all cases and patients’ survival rate in malignant SGTs. HDAC-2 positivity was significantly associated with more prolonged overall survival (OS) of patients with malignant SGTs (p = 0.028), while HDAC-2 positivity and no HDAC-6 expression were associated with prolonged OS of patients with HG malignant SGT (p = 0.003 and p = 0.043, respectively). Additionally, a high HDAC-2 H-score was significantly associated with longer OS for HG malignant SGT patients (p = 0.027). In our study, HDAC-2 expression is a marker for good prognosis, whereas HDAC-6 expression indicated poor prognosis; thus, an inhibitor of HDAC-6 may be used to improve patients’ survival. © 2021 by the authors. Licensee MDPI, Basel, Switzerland."
}