@article{3076725,
    title = "Plasma levels of soluble urokinase plasminogen activator receptor (suPAR) and high-sensitivity C-reactive protein after Roux-en-Y gastric bypass or sleeve gastrectomy: a 1-year prospective observational study",
    author = "Kokkinos, A. and Liaskos, C. and Alexiadou, K. and Papassotiriou, I. and Margeli, A. and Argyrakopoulou, G. and Perrea, D. and Alexandrou, A. and Katsilambros, N. and Diamantis, T. and Tentolouris, N.",
    journal = "Journal of Endocrinological Investigation",
    year = "2021",
    volume = "44",
    number = "3",
    pages = "599-608",
    publisher = "Springer Science and Business Media Deutschland GmbH",
    issn = "0391-4097, 1720-8386",
    doi = "10.1007/s40618-020-01358-7",
    keywords = "C reactive protein;  urokinase receptor;  biological marker;  C reactive protein;  urokinase receptor, adult;  Article;  bariatric surgery;  body mass;  body weight loss;  clinical article;  cohort analysis;  controlled study;  disease severity;  female;  human;  inflammation;  male;  obesity;  observational study;  patient participation;  postoperative period;  preoperative care;  protein blood level;  Roux-en-Y gastric bypass;  sleeve gastrectomy;  treatment duration;  aged;  blood;  body weight loss;  follow up;  gastrectomy;  middle aged;  morbid obesity;  pathology;  procedures;  prospective study;  treatment outcome, Adult;  Aged;  Bariatric Surgery;  Biomarkers;  Body Mass Index;  C-Reactive Protein;  Female;  Follow-Up Studies;  Gastrectomy;  Humans;  Male;  Middle Aged;  Obesity, Morbid;  Prospective Studies;  Receptors, Urokinase Plasminogen Activator;  Treatment Outcome;  Weight Loss",
    abstract = "Purpose: Low-grade inflammation in obesity contributes to the development of cardiovascular disease, diabetes mellitus and cancer, and is associated with increased mortality. The purpose of this 1-year prospective observational study was to examine the weight loss effect of bariatric surgery on plasma concentrations of two inflammatory markers, namely high-sensitivity C-reactive protein (hsCRP) and soluble urokinase-type plasminogen activator receptor (suPAR), in patients with obesity. Methods: Sixteen subjects without obesity and 32 patients with obesity class III, who had already settled upon Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) were included in the study. Subjects without obesity were examined once, at baseline; patients with obesity were examined preoperatively (baseline) and 3, 6 and 12 months postoperatively. Results: Plasma suPAR and hsCRP concentrations at baseline were higher in patients with obesity than in lean participants (2.68 ± 0.86 vs 1.86 ± 0.34 ng/mL, p < 0.001 and 9.83 ± 9.55 vs 1.36 ± 1.95 mg/dL, p < 0.001). Levels of suPAR following bariatric surgery increased significantly 3 months after either RYGB or SG (3.58 ± 1.58 vs 3.26 ± 0.7 ng/mL, respectively) and declined at 6 (3.19 ± 1.75 vs 2.8 ± 0.84 ng/mL, respectively) and 12 months (2.6 ± 1.5 vs 2.22 ± 0.49 ng/mL, respectively; p < 0.05 for the effect of time on suPAR levels during the study), whereas those of hsCRP declined consistently after bariatric surgery (3 months: 5.44 ± 3.99 vs 9.47 ± 11.98 mg/dL, respectively; 6 months; 5.39 ± 5.6 vs 10.25 ± 17.22 mg/dL, respectively; and 12 months: 2.23 ± 2.5 vs 3.07 ± 3.63 mg/dL, respectively; p < 0.001 for the effect of time on hsCRP levels during the study). 1-year change in BMI was negatively associated with suPAR levels at 12 months. Conclusion: Our findings support an association between obesity and low-grade inflammation. Weight loss following bariatric surgery is associated with a consistent decline in plasma hsCRP, while plasma suPAR levels increase at 3 months and decline by 12 months. © 2020, Italian Society of Endocrinology (SIE)."
}