@article{3076899,
    title = "Allium vegetables intake and the risk of gastric cancer in the Stomach cancer Pooling (StoP) Project",
    author = "Dalmartello, M. and Turati, F. and Zhang, Z.-F. and Lunet, N. and Rota, M. and Bonzi, R. and Galeone, C. and Martimianaki, G. and Palli, D. and Ferraroni, M. and Yu, G.-P. and Morais, S. and Malekzadeh, R. and López-Carrillo, L. and Zaridze, D. and Maximovitch, D. and Aragonés, N. and Fernández-Tardón, G. and Martin, V. and Vioque, J. and Garcia de la Hera, M. and Curado, M.P. and Coimbra, F.J.F. and Assumpcao, P. and Pakseresht, M. and Hu, J. and Hernández-Ramírez, R.U. and Ward, M.H. and Pourfarzi, F. and Mu, L. and Tsugane, S. and Hidaka, A. and Lagiou, P. and Lagiou, A. and Trichopoulou, A. and Karakatsani, A. and Boffetta, P. and Camargo, M.C. and Negri, E. and La Vecchia, C. and Pelucchi, C.",
    journal = "British Journal of Cancer",
    year = "2022",
    publisher = "Springer Nature BV",
    issn = "0007-0920, 1532-1827",
    doi = "10.1038/s41416-022-01750-5",
    abstract = "Background: The role of allium vegetables on gastric cancer (GC) risk remains unclear. Methods: We evaluated whether higher intakes of allium vegetables reduce GC risk using individual participant data from 17 studies participating in the “Stomach cancer Pooling (StoP) Project”, including 6097 GC cases and 13,017 controls. Study-specific odds ratios (ORs) were pooled using a two-stage modelling approach. Results: Total allium vegetables intake was inversely associated with GC risk. The pooled OR for the highest versus the lowest study-specific tertile of consumption was 0.71 (95% confidence interval, CI, 0.56–0.90), with substantial heterogeneity across studies (I2 > 50%). Pooled ORs for high versus low consumption were 0.69 (95% CI, 0.55–0.86) for onions and 0.83 (95% CI, 0.75–0.93) for garlic. The inverse association with allium vegetables was evident in Asian (OR 0.50, 95% CI, 0.29–0.86) but not European (OR 0.96, 95% CI, 0.81–1.13) and American (OR 0.66, 95% CI, 0.39–1.11) studies. Results were consistent across all other strata. Conclusions: In a worldwide consortium of epidemiological studies, we found an inverse association between allium vegetables and GC, with a stronger association seen in Asian studies. The heterogeneity of results across geographic regions and possible residual confounding suggest caution in results interpretation. © 2022, The Author(s), under exclusive licence to Springer Nature Limited."
}