@article{3077216,
    title = "Kisspeptin and the Genetic Obesity Interactome",
    author = "S, G. and Pavlopoulou, A. and Lambrou, G.I. and Koutelekos, J. and Cokkinos, D. and Albanopoulos, K. and Chrousos, G.P.",
    journal = "Advances in Experimental Medicine and Biology",
    year = "2021",
    volume = "1339",
    pages = "111-117",
    publisher = "Springer-Verlag",
    doi = "10.1007/978-3-030-78787-5_15",
    keywords = "G protein coupled receptor;  Kiss1 receptor;  kisspeptin;  proopiomelanocortin, genetics;  human;  obesity, Humans;  Kisspeptins;  Obesity;  Pro-Opiomelanocortin;  Receptors, G-Protein-Coupled;  Receptors, Kisspeptin-1",
    abstract = "Background: Kisspeptin (encoded by the KISS1 gene in humans) is an excitatory neuromodulatory peptide implicated in multiple homeostatic systems, including anti-oxidation, glucose homeostasis, nutrition, locomotion, etc. Therefore, in the current obesity epidemic, kisspeptin is gaining increasing interest as a research objective. Aim: To construct an updated interactome of genetic obesity, including the kisspeptin signal transduction pathway. Methods: Kisspeptin and obesity-related genes or gene products were extracted from the biomedical literature, and a network of functional associations was created. Results: The generated network contains 101 nodes corresponding to gene/gene products with known and/or predicted interactions. In this interactome, KISS1 and KISS1R are connected directly to the luteinizing hormone receptor (LHCGR), gonadotropin-releasing hormone receptor (GNRH1), and indirectly, through the latter, to proopiomelanocortin (POMC), glucagon, leptin (LEP), and/or pro-protein convertase subtilisin/kexin-type 1 (PCSK1), all of which are critically implicated in obesity disorders. Conclusions: Our updated obesidome includes kisspeptin and its connections to the genetic obesity signalosome with 12 major hubs: glucagon (GCG), insulin (INS), arginine vasopressin (AVP), G protein subunit beta 1 (GNB1) and proopiomelanocortin (POMC), melanocortin 4 receptor (MC4R), leptin (LEP), gonadotropin-releasing hormone 1 (GNRH1), adrenoceptor beta 2 and 3 (ADRB2-3), glucagon-like peptide 1 receptor (GLP1R), and melanocortin 3 receptor (MC3R) genes were identified as major “hubs” for genetic obesity, providing novel insight into the body’s energy homeostasis. © 2021, The Author(s), under exclusive license to Springer Nature Switzerland AG."
}