@article{3077385,
    title = "A new threat from an old enemy: Re-emergence of coronavirus (Review)",
    author = "Docea, A.O. and Tsatsakis, A. and Albulescu, D. and Cristea, O. and Zlatian, O. and Vinceti, M. and Moschos, S.A. and Tsoukalas, D. and Goumenou, M. and Drakoulis, N. and Dumanov1, J.M. and Tutelyan, V.A. and Onischenko, G.G. and Aschner, M. and Spandidos, D.A. and Calina, D.",
    journal = "International Journal of Molecular Medicine",
    year = "2020",
    volume = "45",
    number = "6",
    pages = "1631-1643",
    publisher = "Spandidos Publications",
    issn = "1107-3756, 1791-244X",
    doi = "10.3892/ijmm.2020.4555",
    keywords = "2,4 thiazolidinedione derivative;  angiotensin converting enzyme 2;  angiotensin receptor antagonist;  antifungal agent;  antihypertensive agent;  antiinfective agent;  chloroquine;  colecalciferol;  consensus interferon;  corticosteroid;  dipeptidyl carboxypeptidase inhibitor;  Human immunodeficiency virus proteinase inhibitor;  ibuprofen;  immunoglobulin;  lopinavir;  lopinavir plus ritonavir;  mycophenolic acid;  remdesivir;  ribavirin;  ritonavir;  sarilumab;  severe acute respiratory syndrome vaccine;  tocilizumab;  virus spike protein, adult respiratory distress syndrome;  age distribution;  artificial ventilation;  case fatality rate;  computer assisted tomography;  contact examination;  coronavirus disease 2019;  Coronavirus infection;  diabetes mellitus;  disease re-emergence;  epidemic;  flu like syndrome;  fomite;  genetic similarity;  ground glass opacity;  human;  hypertension;  intensive care;  Middle East respiratory syndrome;  Middle East respiratory syndrome coronavirus;  nonhuman;  nose smear;  point of care testing;  prevalence;  priority journal;  real time polymerase chain reaction;  respiratory tract parameters;  Review;  SARS coronavirus;  SARS-related coronavirus;  severe acute respiratory syndrome;  Severe acute respiratory syndrome coronavirus 2;  vertical transmission;  virion;  virus entry;  virus genome;  virus infectivity;  virus load;  virus pathogenesis;  virus pneumonia;  virus replication;  virus transmission;  virus virulence;  Betacoronavirus;  Coronavirinae;  Coronavirus infection;  epidemic;  pandemic;  pathogenicity;  physiology;  virology;  virus pneumonia, Betacoronavirus;  Coronavirus;  Coronavirus Infections;  Disease Outbreaks;  Humans;  Pandemics;  Pneumonia, Viral",
    abstract = "The new outbreak of coronavirus from December 2019 has brought attention to an old viral enemy and has raised concerns as to the ability of current protection measures and the healthcare system to handle such a threat. It has been known since the 1960s that coronaviruses can cause respiratory infections in humans; however, their epidemic potential was understood only during the past two decades. © 2020 Spandidos Publications. All rights reserved."
}