@article{3077430,
    title = "Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease",
    author = "Bryois, J. and Skene, N.G. and Hansen, T.F. and Kogelman, L.J.A. and Watson, H.J. and Liu, Z. and Adan, R. and Alfredsson, L. and Ando, T. and Andreassen, O. and Baker, J. and Bergen, A. and Berrettini, W. and Birgegård, A. and Boden, J. and Boehm, I. and Boni, C. and Boraska Perica, V. and Brandt, H. and Breen, G. and Bryois, J. and Buehren, K. and Bulik, C. and Burghardt, R. and Cassina, M. and Cichon, S. and Clementi, M. and Coleman, J. and Cone, R. and Courtet, P. and Crawford, S. and Crow, S. and Crowley, J. and Danner, U. and Davis, O. and de Zwaan, M. and Dedoussis, G. and Degortes, D. and DeSocio, J. and Dick, D. and Dikeos, D. and Dina, C. and Dmitrzak-Weglarz, M. and Docampo Martinez, E. and Duncan, L. and Egberts, K. and Ehrlich, S. and Escaramís, G. and Esko, T. and Estivill, X. and Farmer, A. and Favaro, A. and Fernández-Aranda, F. and Fichter, M. and Fischer, K. and Föcker, M. and Foretova, L. and Forstner, A. and Forzan, M. and Franklin, C. and Gallinger, S. and Gaspar, H. and Giegling, I. and Giuranna, J. and Giusti-Rodríquez, P. and Gonidakis, F. and Gordon, S. and Gorwood, P. and Gratacos Mayora, M. and Grove, J. and Guillaume, S. and Guo, Y. and Hakonarson, H. and Halmi, K. and Hanscombe, K. and Hatzikotoulas, K. and Hauser, J. and Hebebrand, J. and Helder, S. and Henders, A. and Herms, S. and Herpertz-Dahlmann, B. and Herzog, W. and Hinney, A. and Horwood, L.J. and Hübel, C. and Huckins, L. and Hudson, J. and Imgart, H. and Inoko, H. and Janout, V. and Jiménez-Murcia, S. and Johnson, C. and Jordan, J. and Julià, A. and Juréus, A. and Kalsi, G. and Kaminská, D. and Kaplan, A. and Kaprio, J. and Karhunen, L. and Karwautz, A. and Kas, M. and Kaye, W. and Kennedy, J. and Kennedy, M. and Keski-Rahkonen, A. and Kiezebrink, K. and Kim, Y.-R. and Kirk, K. and Klareskog, L. and Klump, K. and Knudsen, G.P. and La Via, M. and Landén, M. and Larsen, J. and Le Hellard, S. and Leppä, V. and Levitan, R. and Li, D. and Lichtenstein, P. and Lilenfeld, L. and Lin, B.D. and Lissowska, J. and Luykx, J. and Magistretti, P. and Maj, M. and Mannik, K. and Marsal, S. and Marshall, C. and Martin, N. and Mattheisen, M. and Mattingsdal, M. and McDevitt, S. and McGuffin, P. and Medland, S. and Metspalu, A. and Meulenbelt, I. and Micali, N. and Mitchell, J. and Mitchell, K. and Monteleone, P. and Monteleone, A.M. and Montgomery, G. and Mortensen, P.B. and Munn-Chernoff, M. and Nacmias, B. and Navratilova, M. and Norring, C. and Ntalla, I. and Olsen, C. and Ophoff, R. and O’Toole, J. and Padyukov, L. and Palotie, A. and Pantel, J. and Papezova, H. and Parker, R. and Pearson, J. and Pedersen, N. and Petersen, L. and Pinto, D. and Purves, K. and Rabionet, R. and Raevuori, A. and Ramoz, N. and Reichborn-Kjennerud, T. and Ricca, V. and Ripatti, S. and Ripke, S. and Ritschel, F. and Roberts, M. and Rotondo, A. and Rujescu, D. and Rybakowski, F. and Santonastaso, P. and Scherag, A. and Scherer, S. and Schmidt, U. and Schork, N. and Schosser, A. and Seitz, J. and Slachtova, L. and Slagboom, P.E. and Slof-Op ‘t Landt, M. and Slopien, A. and Sorbi, S. and Strober, M. and Stuber, G. and Sullivan, P. and Świątkowska, B. and Szatkiewicz, J. and Tachmazidou, I. and Tenconi, E. and Thornton, L. and Tortorella, A. and Tozzi, F. and Treasure, J. and Tsitsika, A. and Tyszkiewicz-Nwafor, M. and Tziouvas, K. and van Elburg, A. and van Furth, E. and Wade, T. and Wagner, G. and Walton, E. and Watson, H. and Werge, T. and Whiteman, D. and Widen, E. and Woodside, D.B. and Yao, S. and Yilmaz, Z. and Zeggini, E. and Zerwas, S. and Zipfel, S. and Anttila, V. and Artto, V. and Belin, A.C. and de Boer, I. and Boomsma, D.I. and Børte, S. and Chasman, D.I. and Cherkas, L. and Christensen, A.F. and Cormand, B. and Cuenca-Leon, E. and Davey-Smith, G. and Dichgans, M. and van Duijn, C. and Esko, T. and Esserlind, A.L. and Ferrari, M. and Frants, R.R. and Freilinger, T. and Furlotte, N. and Gormley, P. and Griffiths, L. and Hamalainen, E. and Hiekkala, M. and Ikram, M.A. and Ingason, A. and Järvelin, M.-R. and Kajanne, R. and Kallela, M. and Kaprio, J. and Kaunisto, M. and Kogelman, L.J.A. and Kubisch, C. and Kurki, M. and Kurth, T. and Launer, L. and Lehtimaki, T. and Lessel, D. and Ligthart, L. and Litterman, N. and Maagdenberg, A. and Macaya, A. and Malik, R. and Mangino, M. and McMahon, G. and Muller-Myhsok, B. and Neale, B.M. and Northover, C. and Nyholt, D.R. and Olesen, J. and Palotie, A. and Palta, P. and Pedersen, L. and Pedersen, N. and Posthuma, D. and Pozo-Rosich, P. and Pressman, A. and Raitakari, O. and Schürks, M. and Sintas, C. and Stefansson, K. and Stefansson, H. and Steinberg, S. and Strachan, D. and Terwindt, G. and Vila-Pueyo, M. and Wessman, M. and Winsvold, B.S. and Zhao, H. and Zwart, J.A. and Agee, M. and Alipanahi, B. and Auton, A. and Bell, R. and Bryc, K. and Elson, S. and Fontanillas, P. and Furlotte, N. and Heilbron, K. and Hinds, D. and Huber, K. and Kleinman, A. and Litterman, N. and McCreight, J. and McIntyre, M. and Mountain, J. and Noblin, E. and Northover, C. and Pitts, S. and Sathirapongsasuti, J. and Sazonova, O. and Shelton, J. and Shringarpure, S. and Tian, C. and Tung, J. and Vacic, V. and Wilson, C. and Brueggeman, L. and Bulik, C.M. and Arenas, E. and Hjerling-Leffler, J. and Sullivan, P.F. and International Headache Genetics Consortium and Eating Disorders Working Group of the Psychiatric Genomics Consortium",
    journal = "Nature Genetics",
    year = "2020",
    volume = "52",
    number = "5",
    pages = "482-493",
    publisher = "Lithuanian Nature Research Centre",
    issn = "1061-4036, 1546-1718",
    doi = "10.1038/s41588-020-0610-9",
    keywords = "hemoglobin A1c;  RNA;  transcriptome, Article;  autism;  bipolar disorder;  body mass;  cells by body anatomy;  cerebrovascular accident;  cholinergic nerve cell;  coronary artery disease;  disease exacerbation;  educational status;  gene expression;  genetic association;  genetic correlation;  genetic identification;  genome-wide association study;  glycemic control;  human;  human tissue;  inflammatory bowel disease;  mental disease;  monoamine nerve cell;  neurologic disease;  neurosis;  non insulin dependent diabetes mellitus;  nonhuman;  oligodendroglia;  Parkinson disease;  parkinsonism;  priority journal;  RNA sequencing;  schizophrenia;  single cell RNA seq;  transcriptomics;  upregulation;  waist hip ratio;  animal;  brain;  genetics;  mouse;  nerve cell;  Parkinson disease;  pathology;  procedures, Animals;  Brain;  Genome-Wide Association Study;  Humans;  Mice;  Neurons;  Parkinson Disease;  Transcriptome",
    abstract = "Genome-wide association studies have discovered hundreds of loci associated with complex brain disorders, but it remains unclear in which cell types these loci are active. Here we integrate genome-wide association study results with single-cell transcriptomic data from the entire mouse nervous system to systematically identify cell types underlying brain complex traits. We show that psychiatric disorders are predominantly associated with projecting excitatory and inhibitory neurons. Neurological diseases were associated with different cell types, which is consistent with other lines of evidence. Notably, Parkinson’s disease was genetically associated not only with cholinergic and monoaminergic neurons (which include dopaminergic neurons) but also with enteric neurons and oligodendrocytes. Using post-mortem brain transcriptomic data, we confirmed alterations in these cells, even at the earliest stages of disease progression. Our study provides an important framework for understanding the cellular basis of complex brain maladies, and reveals an unexpected role of oligodendrocytes in Parkinson’s disease. © 2020, The Author(s), under exclusive licence to Springer Nature America, Inc."
}