@article{3077481,
    title = "Management of supine hypertension in patients with neurogenic orthostatic hypotension: Scientific statement of the American Autonomic Society, European Federation of Autonomic Societies, and the European Society of Hypertension",
    author = "Jordan, J. and Fanciulli, A. and Tank, J. and Calandra-Buonaura, G. and Cheshire, W.P. and Cortelli, P. and Eschlboeck, S. and Grassi, G. and Hilz, M.J. and Kaufmann, H. and Lahrmann, H. and Mancia, G. and Mayer, G. and Norcliffe-Kaufmann, L. and Pavy-Le Traon, A. and Raj, S.R. and Robertson, D. and Rocha, I. and Reuter, H. and Struhal, W. and Thijs, R.D. and Tsioufis, K.P. and Gert Van Dijk, J. and Wenning, G.K. and Biaggioni, I.",
    journal = "JOURNAL OF HYPERTENSION",
    year = "2019",
    volume = "37",
    number = "8",
    pages = "1541-1546",
    publisher = "Lippincott Williams and Wilkins",
    issn = "-",
    doi = "10.1097/HJH.0000000000002078",
    keywords = "adrenergic receptor blocking agent;  antihypertensive agent;  nitric oxide;  vasodilator agent, antihypertensive therapy;  Article;  autonomic dysfunction;  blood pressure regulation;  conservative treatment;  drug efficacy;  drug response;  drug safety;  falling;  human;  hypertension;  kidney disease;  morbidity;  mortality;  neurologic disease;  neuropathy;  night;  orthostatic hypotension;  pathophysiology;  priority journal;  prognosis;  renin angiotensin aldosterone system;  risk benefit analysis;  safety;  sodium excretion;  supine position;  complication;  hypertension;  medical society;  organization and management;  orthostatic hypotension;  physiology;  quality of life;  supine position, Humans;  Hypertension;  Hypotension, Orthostatic;  Quality of Life;  Societies, Medical;  Supine Position",
    abstract = "Supine hypertension commonly occurs in patients with neurogenic orthostatic hypotension due to autonomic failure. Supine hypertension promotes nocturnal sodium excretion and orthostatic hypotension, thus, interfering with quality of life. Perusal of the literature on essential hypertension and smaller scale investigations in autonomic failure patients also suggest that supine hypertension may predispose to cardiovascular and renal disease. These reasons provide a rationale for treating supine hypertension. Yet, treatment of supine hypertension, be it through nonpharmacological or pharmacological approaches, may exacerbate orthostatic hypotension when patients get up during the night. Fall-related complications may occur. More research is needed to define the magnitude of the deleterious effects of supine hypertension on cardiovascular, cerebrovascular, and renal morbidity and mortality. Integration of more precise cardiovascular risk assessment, efficacy, and safety data, and the prognosis of the underlying condition causing autonomic failure is required for individualized management recommendations. © 2019 Wolters Kluwer Health, Inc. All rights reserved."
}