@article{3077527,
    title = "Demographic and clinical features of critically ill patients with COVID-19 in Greece: The burden of diabetes and obesity",
    author = "Halvatsiotis, P. and Kotanidou, A. and Tzannis, K. and Jahaj, E. and Magira, E. and Theodorakopoulou, M. and Konstandopoulou, G. and Gkeka, E. and Pourzitaki, C. and Kapravelos, N. and Papoti, S. and Sileli, M. and Gogos, C. and Velissaris, D. and Markou, N. and Stefanatou, E. and Vlachogianni, G. and Aimoniotou, E. and Komnos, A. and Zafeiridis, T. and Koulouvaris, P. and Armaganidis, A. and Bamias, A. and Dimopoulos, G.",
    journal = "Diabetes Research and Clinical Practice",
    year = "2020",
    volume = "166",
    publisher = "Elsevier Ireland Ltd",
    issn = "0168-8227",
    doi = "10.1016/j.diabres.2020.108331",
    keywords = "adult;  aged;  aging;  Article;  clinical feature;  comorbidity;  coronavirus disease 2019;  critical illness;  critically ill patient;  demography;  disease burden;  disease duration;  disease severity;  female;  Greece;  hospital admission;  hospital discharge;  human;  hypertension;  infection risk;  intensive care unit;  length of stay;  major clinical study;  male;  mortality;  non insulin dependent diabetes mellitus;  obesity;  observational study;  retrospective study;  Betacoronavirus;  clinical trial;  complication;  Coronavirus infection;  critical illness;  diabetes mellitus;  hospitalization;  isolation and purification;  middle aged;  mortality;  multicenter study;  obesity;  pandemic;  pathophysiology;  prognosis;  risk factor;  survival rate;  virology;  virus pneumonia, Aged;  Betacoronavirus;  Comorbidity;  Coronavirus Infections;  Critical Illness;  Diabetes Mellitus;  Female;  Greece;  Hospitalization;  Humans;  Male;  Middle Aged;  Obesity;  Pandemics;  Pneumonia, Viral;  Prognosis;  Retrospective Studies;  Risk Factors;  Survival Rate",
    abstract = "Aims: The aim of the study was to investigate the association between type-2 diabetes mellitus, other underlying diseases and obesity with the outcomes of critically ill Covid-19 patients in Greece. Methods: In this retrospective observational multi-centre study, data and outcomes of 90 RNA 2109-nCoV confirmed critically ill patients from 8 hospitals throughout Greece, were analysed. All reported information stand through April 13th 2020. Results: The median age of the patients was 65.5 (IQR 56–73), majority were male (80%) and obesity was present in 34.4% of patients most prevalent to younger than 55 years. Hypertension was the prevailing comorbidity (50%), followed by cardiovascular diseases (21.1%) and type-2 diabetes (18.9%). At admission, common symptoms duration had a median of 8 (IQR 5–11) days. A 13.3% of the patients were discharged, 53.4% were still in the ICUs and 28.9% deceased who were hospitalised for fewer days than the survivors [6 (IQR 3–9) vs. 9 (IQR 7–14.5) respectively]. Aging was not a risk factor but diabetes deteriorates the outcomes. Obesity poses a suggestive burden as it was more notable in deceased versus survivors. Conclusions: Type 2 diabetes and obesity may have contributed to disease severity and mortality in COVID-19 critically ill patients in Greece. © 2020 Elsevier B.V."
}