@article{3078031,
    title = "Association between Biomarkers of Low-grade Inflammation and Sex Hormones in Women with Polycystic Ovary Syndrome",
    author = "Hatziagelaki, E. and Pergialiotis, V. and Kannenberg, J.M. and Trakakis, E. and Tsiavou, A. and Markgraf, D.F. and Carstensen-Kirberg, M. and Pacini, G. and Roden, M. and Dimitriadis, G. and Herder, C., Prof. Dr.",
    journal = "Experimental and Clinical Endocrinology and Diabetes",
    year = "2020",
    volume = "128",
    number = "11",
    pages = "723-730",
    publisher = "Georg Thieme Verlag",
    doi = "10.1055/a-0992-9114",
    keywords = "17 oh progesterone;  androstenedione;  biological marker;  carbon tetrachloride;  caspase 8;  cholesterol;  colony stimulating factor 1;  CXCL1 chemokine;  CXCL11 chemokine;  cystatin;  cystatin d;  epithelial derived neutrophil activating factor 78;  estrogen;  follitropin;  fractalkine;  globulin;  granulocyte chemotactic protein 2;  herpesvirus entry mediator ligand;  interleukin 8;  interstitial collagenase;  luteinizing hormone;  monocyte chemotactic protein 4;  prasterone sulfate;  progesterone;  prolactin;  sex hormone;  sex hormone binding globulin;  testosterone;  transforming growth factor beta1;  unclassified drug;  vasculotropin A;  chemokine;  estrogen;  luteinizing hormone;  progesterone;  prolactin;  sex hormone;  sex hormone binding globulin;  SHBG protein, human;  testosterone, adult;  age;  anthropometry;  Article;  biochemical analysis;  body mass;  cardiometabolic risk;  cholesterol blood level;  clinical feature;  comorbidity;  cross-sectional study;  estrogen blood level;  female;  hip circumference;  human;  inflammation;  low grade inflammation;  major clinical study;  ovary polycystic disease;  priority journal;  waist circumference;  blood;  body mass;  inflammation;  metabolism;  ovary polycystic disease, Adult;  Body Mass Index;  Chemokines;  Estrogens;  Female;  Gonadal Steroid Hormones;  Humans;  Inflammation;  Luteinizing Hormone;  Polycystic Ovary Syndrome;  Progesterone;  Prolactin;  Sex Hormone-Binding Globulin;  Testosterone",
    abstract = "Objective Women with polycystic ovary syndrome (PCOS) have higher circulating levels of C-reactive protein, but the relationship between inflammation and endocrine function in PCOS remains poorly understood. Thus, this study aimed to investigate the association between low-grade inflammation and sex hormones in women with PCOS. Design and Patients A comprehensive panel of biomarkers of inflammation was measured in serum of 63 women with PCOS using proximity extension assay technology. Associations of 65 biomarkers with sex hormones were assessed without and with adjustment for age and body mass index (BMI). Results In the unadjusted analysis, 20 biomarkers were positively correlated with 17-OH-progesterone (17-OH-P), 14 with prolactin and 6 with free testosterone, whereas inverse associations were found for 16 biomarkers with sex hormone-binding globulin (SHBG), 6 with luteinizing hormone (LH) and 6 with estrogen (all p<0.05). Among the positive associations, correlations were mainly found for five chemokines (CXCL11, CCL4, MCP-4/CCL13, CXCL5, CXCL6) and for VEGF-A, LAP-TGFβ1, TNFSF14 and MMP-1. Inverse associations with sex hormones were mainly present for two chemokines (CXCL1, MCP-2/CCL8), CDCP1, CST5 and CSF-1. Adjustment for age and BMI reduced the number of biomarker associations for SHBG and estrogen, but had hardly any impact on associations with 17-OH-P, prolactin, free testosterone and LH. Conclusion Women with PCOS feature BMI-independent associations between biomarkers of inflammation and certain sex steroid and hypophyseal hormones. Most of these inflammation-related biomarkers were chemokines, which may be relevant as potential mediators of the increased cardiometabolic risk of women with PCOS. © 2020 Royal Society of Chemistry. All rights reserved."
}