@article{3078075,
    title = "The role of E3, E4 ubiquitin ligase (UBE4B) in human pathologies",
    author = "Antoniou, N. and Lagopati, N. and Balourdas, D.I. and Nikolaou, M. and Papalampros, A. and Vasileiou, P.V.S. and Myrianthopoulos, V. and Kotsinas, A. and Shiloh, Y. and Liontos, M. and Gorgoulis, V.G.",
    journal = "JMIR Cancer",
    year = "2020",
    volume = "12",
    number = "1",
    publisher = "MDPI AG",
    doi = "10.3390/cancers12010062",
    keywords = "proteasome;  protein p53;  ubiquitin protein ligase;  ubiquitin protein ligase E3;  ubiquitin protein ligase E4;  unclassified drug, carcinogenesis;  degenerative disease;  DNA damage response;  gene;  genetic association;  human;  malignant neoplasm;  neuropathology;  nonhuman;  predictive value;  protein expression;  protein function;  Review;  single nucleotide polymorphism;  UBE4B gene;  ubiquitination",
    abstract = "The genome is exposed daily to many deleterious factors. Ubiquitination is a mechanism that regulates several crucial cellular functions, allowing cells to react upon various stimuli in order to preserve their homeostasis. Ubiquitin ligases act as specific regulators and actively participate among others in the DNA damage response (DDR) network. UBE4B is a newly identified member of E3 ubiquitin ligases that appears to be overexpressed in several human neoplasms. The aim of this review is to provide insights into the role of UBE4B ubiquitin ligase in DDR and its association with p53 expression, shedding light particularly on the molecular mechanisms of carcinogenesis. © 2019 by the authors. Licensee MDPI, Basel, Switzerland."
}