@article{3078466,
    title = "Usefulness of the SAGE score to predict elevated values of brachial-ankle pulse wave velocity in Japanese subjects with hypertension",
    author = "Tomiyama, H. and Vlachopoulos, C. and Xaplanteris, P. and Nakano, H. and Shiina, K. and Ishizu, T. and Kohro, T. and Higashi, Y. and Takase, B. and Suzuki, T. and Yamazaki, T. and Furumoto, T. and Kario, K. and Inoue, T. and Koba, S. and Takemoto, Y. and Hano, T. and Sata, M. and Ishibashi, Y. and Node, K. and Tanaka, A. and Maemura, K. and Ohya, Y. and Furukawa, T. and Ito, H. and Ohkuma, T. and Ninomiya, T. and Chikamori, T. and Yamashina, A. and Ueda, S.-I.",
    journal = "Hypertension Research",
    year = "2020",
    volume = "43",
    number = "11",
    pages = "1284-1292",
    publisher = "Springer Nature BV",
    issn = "0916-9636, 1348-4214",
    doi = "10.1038/s41440-020-0472-7",
    keywords = "cholesterol;  creatinine;  high density lipoprotein cholesterol, adult;  aged;  Article;  atrial fibrillation;  brachial-ankle pulse wave velocity;  Chronic Kidney Disease Epidemiology Collaboration equation;  cohort analysis;  controlled study;  cross-sectional study;  diagnostic test accuracy study;  diastolic blood pressure;  estimated glomerular filtration rate;  female;  glucose blood level;  human;  hypertension;  Japanese (people);  kidney function;  major clinical study;  male;  mathematical parameters;  multicenter study;  observational study;  prospective study;  receiver operating characteristic;  SAGE score;  scoring system;  sensitivity and specificity;  systolic blood pressure;  waveform;  health status indicator;  hypertension;  Japan;  middle aged;  pathophysiology;  pulse wave, Adult;  Aged;  Cross-Sectional Studies;  Female;  Health Status Indicators;  Humans;  Hypertension;  Japan;  Male;  Middle Aged;  Pulse Wave Analysis",
    abstract = "The score based on the office systolic blood pressure, age, fasting blood glucose level, and estimated glomerular filtration rate (SAGE score) has been proposed as a useful marker to identify elevated values of carotid-femoral pulse wave velocity (PWV). The present cross-sectional study was conducted to examine whether the SAGE score is also a useful marker to identify subjects with elevated brachial-ankle PWV values in Japanese subjects with hypertension. We measured the brachial-ankle PWV and calculated the SAGE score in a total of 1019 employees of a Japanese company with hypertension and 817 subjects with hypertension derived from a multicenter study cohort. The analyses in this study were based on data from these two study groups as well as on a composite population of the two (n = 1836). The receiver operating characteristic curve analysis showed that the area under the curve to identify subjects with brachial-ankle PWV values of ≥1800 cm/s was over 0.70 in each of the three study groups. Even after adjustments, a SAGE score ≥7 had a significant odds ratio for identifying subjects with brachial-ankle PWV values ≥1800 cm/s in the 1836 study subjects from the composite occupational and multicenter study cohort (odds ratio = 2.1, 95% confidence interval = 1.4–3.0, P < 0.01). Thus, in Japanese subjects with hypertension, the SAGE score may be a useful marker for identifying subjects with elevated brachial-ankle PWV values. © 2020, The Japanese Society of Hypertension."
}