@article{3078640,
    title = "Endothelial progenitor cells and peripheral neuropathy in subjects with type 2 diabetes mellitus",
    author = "Eleftheriadou, I. and Dimitrakopoulou, N. and Kafasi, N. and Tentolouris, A. and Dimitrakopoulou, A. and Anastasiou, I.A. and Mourouzis, I. and Jude, E. and Tentolouris, N.",
    journal = "Journal of Diabetes and its Complications",
    year = "2020",
    volume = "34",
    number = "4",
    publisher = "W B SAUNDERS CO-ELSEVIER INC",
    issn = "1056-8727",
    doi = "10.1016/j.jdiacomp.2019.107517",
    keywords = "CD133 antigen;  CD34 antigen;  dipeptidyl peptidase IV inhibitor;  glucose;  hemoglobin A1c;  insulin;  intercellular adhesion molecule 1;  metformin;  platelet endothelial cell adhesion molecule 1;  stromal cell derived factor 1;  tumor necrosis factor;  vascular cell adhesion molecule 1;  vasculotropin;  vasculotropin receptor 2, adult;  ankle pressure;  Article;  blood sampling;  cardiovascular risk;  cell adhesion;  cell isolation;  chronic kidney failure;  controlled study;  cross-sectional study;  diabetic nephropathy;  diabetic neuropathy;  diabetic patient;  diabetic retinopathy;  disease duration;  endothelial progenitor cell;  female;  flow cytometry;  glucose blood level;  human;  human cell;  major clinical study;  male;  microalbuminuria;  middle aged;  non insulin dependent diabetes mellitus;  observational study;  pathogenesis;  peripheral neuropathy;  physical examination;  priority journal;  protein blood level;  aged;  blood;  case control study;  complication;  diabetic neuropathy;  endothelial progenitor cell;  non insulin dependent diabetes mellitus;  pathology;  peripheral neuropathy, Adult;  Aged;  Case-Control Studies;  Cross-Sectional Studies;  Diabetes Mellitus, Type 2;  Diabetic Neuropathies;  Endothelial Progenitor Cells;  Female;  Flow Cytometry;  Humans;  Male;  Middle Aged;  Peripheral Nervous System Diseases",
    abstract = "Aims: To examine for differences in circulating progenitor cells (CPCs) and endothelial progenitor cells (EPCs) in patients with and without diabetic peripheral neuropathy (DPN). Methods: A total of 105 participants were included: 50 patients with type 2 diabetes (T2DM) and DPN, 30 patients with T2DM without DPN and 25 healthy individuals. CPCs and 6 different EPCs phenotypes were assessed with flow cytometry. We also measured plasma levels of vascular endothelial growth factor (VEGF), stromal cell-derived factor 1 (SDF-1), vascular cell adhesion protein-1 (VCAM-1), intracellular adhesion molecule-1 (ICAM) and tumor necrosis factor a (TNFa). Results: No difference was observed in the number of CPCs among the 3 groups. Patients with DPN had higher numbers of all 6 EPCs phenotypes when compared with patients without DPN and higher number of 5 EPCs phenotypes when compared with healthy individuals. Plasma VEFG, VCAM-1, ICAM-1 and TNFa levels did not differ among the 3 groups. Patients with DPN had lower SDF-1 levels in comparison with healthy individuals. Conclusion: Circulating EPCs are increased while SDF-1 levels are decreased in the presence of DPN. Our findings suggest that DPN may be associated with impaired trafficking of EPCs and impaired EPCs homing to the injured endothelium. © 2020 Elsevier Inc."
}