@article{3078662,
    title = "Tumor mutational patterns and infiltrating lymphocyte density in young and elderly patients with breast cancer",
    author = "Nikolaidi, A. and Kotoula, V. and Koliou, G.-A. and Giannoulatou, E. and Papadopoulou, K. and Zagouri, F. and Pentheroudakis, G. and Gogas, H. and Bobos, M. and Chatzopoulos, K. and Oikonomopoulos, G. and Pectasides, D. and Saloustros, E. and Arnogiannaki, N. and Nicolaou, I. and Papakostas, P. and Bompolaki, I. and Aravantinos, G. and Athanasiadis, I. and Fountzilas, G.",
    journal = "Cancer Genomics and Proteomics",
    year = "2020",
    volume = "17",
    number = "2",
    pages = "181-193",
    publisher = "International Institute of Anticancer Research",
    doi = "10.21873/cgp.20179",
    keywords = "transcription factor GATA 3;  trastuzumab;  tumor marker, adjuvant chemotherapy;  adult;  aged;  Article;  breast cancer;  cancer patient;  cancer prognosis;  cell density;  controlled study;  disease free survival;  female;  follow up;  gene mutation;  genotype;  groups by age;  human;  human tissue;  major clinical study;  tumor associated leukocyte;  breast tumor;  genetics;  metabolism;  mutation;  pathology;  prognosis;  tumor associated leukocyte, Adult;  Aged;  Biomarkers, Tumor;  Breast Neoplasms;  Female;  Humans;  Lymphocytes, Tumor-Infiltrating;  Mutation;  Prognosis",
    abstract = "Background/Aim: Age may pertain to different tumor genotype characteristics which may interfere with treatment efficacy and prognosis. We investigated the distribution and prognostic effect of mutations and tumor infiltrating lymphocyte (stromal TIL density) in young (≤35 years) and elderly (>65 years) early breast cancer patients. Materials and Methods: Paraffin tumor genotypes of all clinical subtypes from 345 patients were examined. Results: A total of 638 mutations were detected in 221 patients (64.1%). Compared to young, elderly patients presented with lower TIL density (p<0.001) but more TILs in TP53 mutated tumors (p=0.042). Mutation in one, rather than in 2 or more genes, conferred better outcome (DFS: HR=0.51, p=0.016; OS: HR=0.47, p=0.015) but the effect was age-independent. Conclusion: There are fewer TILs and different mutations patterns in tumors from elderly patients compared to young. Age and TIL-independent gene agnostic co-mutations affect patient outcome. © 2020 International Institute of Anticancer Research. All rights reserved."
}