@article{3079991,
    title = "Re-analysis of human immunodeficiency virus type 1 isolates from Cyprus
and Greece, initially designated `subtype I', reveals a unique complex
A/G/H/K/? mosaic pattern",
    author = "Paraskevis, D and Magiorkinis, M and Vandamme, AM and Kostrikis, LG and and Hatzakis, A",
    journal = "Journal of General Virology",
    year = "2001",
    volume = "82",
    number = "3",
    pages = "575-580",
    publisher = "SOC GENERAL MICROBIOLOGY",
    issn = "0022-1317, 1465-2099",
    doi = "10.1099/0022-1317-82-3-575",
    abstract = "Human immunodeficiency virus type 1 (HIV-1) has been classified into
three main groups and 11 distinct subtypes. Moreover, several
circulating recombinant forms (CRFs) of HIV-1 have been recently
documented to have spread widely causing extensive HIV-1 epidemics. A
subtype, initially designated I (CRF04_cpx), was documented in Cyprus
and Greece and was found to comprise regions of sequence derived from
subtypes A and G as well as regions of unclassified sequence. Reanalysis
of the three full-length CRF04_cpx sequences that were available
revealed a mosaic genomic organization of unique complexity comprising
regions of sequence from at least five distinct subtypes, A, G, H, K and
unclassified regions. These strains account for approximately 2% of the
total HIV-1-infected population in Greece, thus providing evidence of
the great capability of HIV-1 to recombine and produce highly divergent
strains which can be spread successfully through different infection
routes."
}