@article{3081313,
    title = "Excess of allele1 for alpha 3 subunit GABA receptor gene (GABRA3) in
bipolar patients: a multicentric association study",
    author = "Massat, I and Souery, D and Del-Favero, J and Oruc, L and Noethen, MM and and Blackwood, D and Thomson, M and Muir, W and Papadimitriou, GN and and Dikeos, DG and Kaneva, R and Serretti, A and Lilli, R and Smeraldi, E and and Jakovljevic, M and Folnegovic, V and Rietschel, M and Milanov, V and and Valente, F and Van Broeckhoven, C and Mendlewicz, J",
    journal = "Journal of Molecular Psychiatry",
    year = "2002",
    volume = "7",
    number = "2",
    pages = "201-207",
    publisher = "Nature Publishing Group",
    issn = "2049-9256",
    doi = "10.1038/sj.mp.4000953",
    keywords = "GABRA3; association study; candidate gene; chromosome X; bipolar
disorder",
    abstract = "The available data from preclinical and pharmacological studies on the
role of gamma amino butyric acid (GABA) support the hypothesis that a
dysfunction in brain GABAergic system activity contributes to the
vulnerability to bipolar affective disorders (BPAD). Moreover, the
localization of the alpha3 subunit GABA receptor GABRA3 gene on the
Xq28, a region of interest in certain forms of bipolar illness, suggests
that GABRA3 may be a candidate gene in BPAD. In the present study, we
tested the genetic contribution of the GABRA3 dinucleotide polymorphism
in a European multicentric case-control sample, matched for sex and
ethnogeographical origin. Allele and genotype (in females) frequencies
were compared in 185 BPAD patients and 370 controls. A significant
increase of genotype 1-1 was observed in BPAD females compared to
controls (P=0.0004). Furthermore, when considering recessivity of allele
1 (females with genotype 1-1 and males carrying allele 1), results were
even more significant (P=0.00002). Our findings suggest that the GABRA3
polymorphism may confer susceptibility to or may be in linkage
disequilibrium with another gene involved in the genetic etiology of
BPAD."
}