@article{3081730, title = "No major schizophrenia locus detected on chromosome 1q in a large multicenter sample", author = "Levinson, DF and Holmans, PA and Laurent, C and Riley, B and Pulver, AE and and Gejman, PV and Schwab, SG and Williams, NM and Owen, MJ and and Wildenauer, DB and Sanders, AR and Nestadt, G and Mowry, BJ and Wormley, and B and Bauche, S and Soubigou, S and Ribble, R and Nertney, DA and Liang, and KY and Martinolich, L and Maier, W and Norton, N and Williams, H and and Albus, M and Carpenter, EB and deMarchi, N and Ewen-White, KR and Walsh, and D and Jay, M and Deleuze, JF and O'Neill, FA and Papadimitriou, G and and Weilbaecher, A and Lerer, B and O'Donovan, MC and Dikeos, D and and Silverman, JM and Kendler, KS and Mallet, J and Crowe, RR and Walters, M", journal = "SCIENCE CHINA Information Sciences", year = "2002", volume = "296", number = "5568", pages = "739-741", publisher = "AMER ASSOC ADVANCEMENT SCIENCE", doi = "10.1126/science.1069914", abstract = "Reports of substantial evidence for genetic linkage of schizophrenia to chromosome 1q were evaluated by genotyping 16 DNA markers across 107 centimorgans of this chromosome in a multicenter sample of 779 informative schizophrenia pedigrees. No significant evidence was observed for such linkage, nor for heterogeneity in allele sharing among the eight individual samples. Separate analyses of European-origin families, recessive models of inheritance, and families with larger numbers of affected cases also failed to produce significant evidence for linkage. If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small." }