@article{3081829,
    title = "Uptake and washout of (TcV)-Tc-99m-dimercaptosuccinic acid and
Tc-99m-sestamibi in the assessment of histological type and grade in
breast cancer",
    author = "Papantoniou, V and Christodoulidou, J and Papadaki, E and Valotassiou, V and and Souvatzoglou, M and Louvrou, A and Feida, H and Sotiropoulou, M and and Pampouras, G and Michalas, S and Zerva, C",
    journal = "Nuclear Medicine Communications",
    year = "2002",
    volume = "23",
    number = "5",
    pages = "461-467",
    publisher = "Lippincott, Williams & Wilkins",
    issn = "0143-3636, 1473-5628",
    doi = "10.1097/00006231-200205000-00006",
    keywords = "(99m)-Tc(V)-DMSA; Tc-99m-MIBI; breast cancer; histology",
    abstract = "This study was performed to investigate the relationship between
histological type and grade, with the uptake and washout of
Tc-99m-hexakis-2-methoxyisobutylisonitrile (Tc-99m-sestamibi,
Tc-99m-MIBI) and Tc-99m(V)-dimercaptosuccinic acid ((TcV)-Tc-99m-DMSA)
in breast cancer. Forty-five patients with histologically proven breast
cancer had previously been referred for (TcV)-Tc-99m-DMSA and/or
Tc-99m-MIBI scintimammography. Twenty-five of them underwent both
99mTcV-DMSA and Tc-99m-MIBI scintigraphy in a double phase study.
Lateral prone and anterior supine images were acquired at 15 and 60 min
after administration of 740-925 MBq of each radiotracer. Uptake ratios
and retention index were calculated and correlated with histology and
grade of malignancy. Histology showed eight different histotypes: 77.7%
were infiltrating ductal or lobular carcinomas. Mammography was
definitely positive in 32/45, indeterminate in 10 and negative in three
cases (sensitivity 71%). (TcV)-Tc-99m-DMSA was true positive in 37/40
(sensitivity 92.5%) and Tc-99m-MIBI in 28/30 (sensitivity 93.3%)
breast cancers. Uptake ratios were significantly higher in ductal than
in lobular carcinomas on (TcV)-Tc-99m-DMSA and Tc-99m-MIBI scintigrams
at early and delayed phases. Grade II carcinomas had significantly lower
values of retention index (rapid washout) than grade III carcinomas.
This finding was statistically significant only on Tc-99m-MIBI scans and
was observed in ductal and lobular carcinomas. The retention index did
not show any significant difference between ductal and lobular
carcinomas. Uptake ratios were also not statistically different between
grade II and III cancers. It is concluded that Tc-99m-MIBI and
(TcV)-Tc-99m-DMSA uptake in breast cancer is probably related to
histological type and may distinguish ductal from lobular carcinomas. To
a certain degree, the washout rate may reflect the histological grade,
but since grade is not the only factor influencing this phenomenon it
should be explored further in conjunction with other parameters by
multivariate analysis in order to clarify eventual indirect
correlations. (C) 2002 Lippincott Williams Wilkins)."
}