@article{3084600,
    title = "Urinary excretion of endothelin-1 in children with absorptive idiopathic
hypercalciuria",
    author = "Nicolaidou, P and Georgouli, H and Getsi, V and Tsapra, H and Psychou, F and and Matsinos, YG and Zeis, PM and Gourgiotis, D",
    journal = "Pediatric Nephrology",
    year = "2003",
    volume = "18",
    number = "11",
    pages = "1157-1160",
    publisher = "Springer-Verlag",
    issn = "0931-041X, 1432-198X",
    doi = "10.1007/s00467-003-1263-5",
    keywords = "endothelin; calcium; hypercalciuria",
    abstract = "Urinary excretion of endothelin-1 (ET-1) and plasma ET-1 were measured
in 21 children with absorptive idiopathic hypercalciuria (AIH) and 22
controls. The absorptive type of idiopathic hypercalciuria was
determined by a calcium loading test. Daily urinary excretion of ET-1
and urinary ET-1/creatinine ratio were significantly increased (P=0.005
and P=0.007, respectively) in patients with AIH (9,274+/-6,444 pg/24 h
and 14.04+/-9.52 pg/mg, respectively) compared with controls
(4,699+/-2,120 pg/24 h and 7.36+/-4.71 pg/mg, respectively). Plasma ET-1
levels were significantly lower in patients with AIH (0.84+/-0.64 pg/ml)
than in controls (1.54+/-0.54 pg/ml, P=0.0001). In conclusion, patients
with AIH had increased urinary ET-1 excretion and decreased plasma ET-1
levels. This is most likely due to the decreased reabsorption of ET-1 in
the renal tubule and increased renal production."
}