@article{3085528,
    title = "Making sense of big data in health research: Towards an EU action plan",
    author = "Auffray, C. and Balling, R. and Barroso, I. and Bencze, L. and Benson, M. and Bergeron, J. and Bernal-Delgado, E. and Blomberg, N. and Bock, C. and Conesa, A. and Del Signore, S. and Delogne, C. and Devilee, P. and Di Meglio, A. and Eijkemans, M. and Flicek, P. and Graf, N. and Grimm, V. and Guchelaar, H.-J. and Guo, Y.-K. and Gut, I.G. and Hanbury, A. and Hanif, S. and Hilgers, R.-D. and Honrado and Hose, D.R. and Houwing-Duistermaat, J. and Hubbard, T. and Janacek, S.H. and Karanikas, H. and Kievits, T. and Kohler, M. and Kremer, A. and Lanfear, J. and Lengauer, T. and Maes, E. and Meert, T. and Müller, W. and Nickel, D. and Oledzki, P. and Pedersen, B. and Petkovic, M. and Pliakos, K. and Rattray, M. and i Màs, J.R. and Schneider, R. and Sengstag, T. and Serra-Picamal, X. and Spek, W. and Vaas, L.A.I. and van Batenburg, O. and Vandelaer, M. and Varnai, P. and Villoslada, P. and Vizcaíno, J.A. and Wubbe, J.P.M. and Zanetti, G.",
    journal = "Genome Medicine",
    year = "2016",
    volume = "8",
    number = "1",
    publisher = "BioMed Central Ltd.",
    issn = "1756-994X",
    doi = "10.1186/s13073-016-0323-y",
    keywords = "Article;  data analysis;  electronic health record;  Europe;  gene sequence;  genetic database;  genome analysis;  government regulation;  health care system;  human;  legal aspect;  mathematical model;  medical education;  medical research;  nonhuman;  patient information;  patient registry;  priority journal;  process model;  register;  sequence analysis;  European Union;  factual database;  health care planning;  information dissemination;  legislation and jurisprudence;  medical research;  organization and management;  standards, Biomedical Research;  Databases, Factual;  European Union;  Health Plan Implementation;  Humans;  Information Dissemination",
    abstract = "Medicine and healthcare are undergoing profound changes. Whole-genome sequencing and high-resolution imaging technologies are key drivers of this rapid and crucial transformation. Technological innovation combined with automation and miniaturization has triggered an explosion in data production that will soon reach exabyte proportions. How are we going to deal with this exponential increase in data production? The potential of "big data" for improving health is enormous but, at the same time, we face a wide range of challenges to overcome urgently. Europe is very proud of its cultural diversity; however, exploitation of the data made available through advances in genomic medicine, imaging, and a wide range of mobile health applications or connected devices is hampered by numerous historical, technical, legal, and political barriers. European health systems and databases are diverse and fragmented. There is a lack of harmonization of data formats, processing, analysis, and data transfer, which leads to incompatibilities and lost opportunities. Legal frameworks for data sharing are evolving. Clinicians, researchers, and citizens need improved methods, tools, and training to generate, analyze, and query data effectively. Addressing these barriers will contribute to creating the European Single Market for health, which will improve health and healthcare for all Europeans. © 2016 The Author(s)."
}