@article{3085945,
    title = "Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging",
    author = "Gonos, E.S. and Kapetanou, M. and Sereikaite, J. and Bartosz, G. and Naparlo, K. and Grzesik, M. and Sadowska-Bartosz, I.",
    journal = "Aging (Albany NY)",
    year = "2018",
    volume = "10",
    number = "5",
    pages = "868-901",
    publisher = "Impact Journals, LLC",
    doi = "10.18632/aging.101450",
    keywords = "aging;  animal;  brain disease;  halogenation;  human;  metabolism;  oxidative stress;  pathophysiology;  physiology;  protein carbonylation;  protein processing, Aging;  Animals;  Brain Diseases;  Halogenation;  Humans;  Oxidative Stress;  Protein Carbonylation;  Protein Processing, Post-Translational",
    abstract = "Non-enzymatic protein modifications occur inevitably in all living systems. Products of such modifications accumulate during aging of cells and organisms and may contribute to their age-related functional deterioration. This review presents the formation of irreversible protein modifications such as carbonylation, nitration and chlorination, modifications by 4-hydroxynonenal, removal of modified proteins and accumulation of these protein modifications during aging of humans and model organisms, and their enhanced accumulation in age-related brain diseases. © 2018, Gonos et al."
}