@article{3086268,
    title = "Squamous cell carcinoma of the pancreas: A systematic review and pooled survival analysis",
    author = "Ntanasis-Stathopoulos, I. and Tsilimigras, D.I. and Georgiadou, D. and Kanavidis, P. and Riccioni, O. and Salla, C. and Psaltopoulou, T. and Sergentanis, T.N.",
    journal = "EUROPEAN JOURNAL OF CANCER",
    year = "2017",
    volume = "79",
    pages = "193-204",
    publisher = "Elsevier Ireland Ltd",
    doi = "10.1016/j.ejca.2017.04.006",
    keywords = "adult;  cancer prognosis;  cancer staging;  cancer surgery;  cancer survival;  female;  human;  information retrieval;  major clinical study;  male;  Medline;  overall survival;  pancreas carcinoma;  priority journal;  proportional hazards model;  recurrence free survival;  Review;  squamous cell carcinoma;  survival analysis;  systematic review;  aged;  Kaplan Meier method;  meta analysis;  middle aged;  mortality;  pancreas tumor;  pathology;  squamous cell carcinoma;  treatment outcome;  tumor volume;  very elderly, Adult;  Aged;  Aged, 80 and over;  Carcinoma, Squamous Cell;  Female;  Humans;  Kaplan-Meier Estimate;  Male;  Middle Aged;  Pancreatic Neoplasms;  Treatment Outcome;  Tumor Burden",
    abstract = "The diagnosis and treatment of squamous cell carcinoma of the pancreas pose dilemmas in the clinical practice. The present study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Eligible articles were sought in MEDLINE up to 30th April 2016. A pooled Cox regression analysis was performed to evaluate factors potentially associated with overall survival (OS) and relapse-free survival (RFS). Fifty-four cases of pure squamous cell pancreatic carcinomas were identified in total. The mean age was 61.9 years, and most patients were males (61.1%). The median OS was 7 months. Resectability (p = 0.003) and more recent publication year (p < 0.001) were associated with better OS, as was low/intermediate tumour grade (p = 0.032) with RFS. Despite its poor prognosis, survival rates of pancreatic squamous cell carcinoma seem improved during the recent years; resectability and low/intermediate grade emerged as favourable prognostic factors. Collaborative epidemiological studies are deemed necessary to further validate the results stemming from the published case reports of this rare entity. © 2017 Elsevier Ltd"
}