@article{3086592,
    title = "Genetic factors related with early onset of osteonecrosis of the jaw in patients with multiple myeloma under zoledronic acid therapy",
    author = "Kastritis, E. and Melea, P. and Bagratuni, T. and Melakopoulos, I. and Gavriatopoulou, M. and Roussou, M. and Migkou, M. and Eleutherakis-Papaiakovou, E. and Terpos, E. and Dimopoulos, M.A.",
    journal = "Clinical Lymphoma Myeloma and Leukemia",
    year = "2017",
    volume = "58",
    number = "10",
    pages = "2304-2309",
    publisher = "Taylor and Francis Ltd.",
    doi = "10.1080/10428194.2017.1300889",
    keywords = "cytochrome P450 2C8;  peroxisome proliferator activated receptor gamma;  zoledronic acid;  bone density conservation agent;  CYP2C8 protein, human;  cytochrome P450 2C8;  peroxisome proliferator activated receptor gamma;  PPARG protein, human;  zoledronic acid, adult;  Article;  cancer chemotherapy;  female;  follow up;  genetic association;  genotype;  heredity;  human;  jaw osteonecrosis;  major clinical study;  male;  middle aged;  mouth hygiene;  multiple myeloma;  priority journal;  prospective study;  risk assessment;  single nucleotide polymorphism;  genetics;  jaw osteonecrosis;  risk factor;  single nucleotide polymorphism, Bisphosphonate-Associated Osteonecrosis of the Jaw;  Bone Density Conservation Agents;  Cytochrome P-450 CYP2C8;  Humans;  Multiple Myeloma;  Polymorphism, Single Nucleotide;  PPAR gamma;  Risk Factors;  Zoledronic Acid",
    abstract = "Specific genetic polymorphisms (SNPs) have been correlated with the development of bisphosphonate-related osteonecrosis of the jaw (BRONJ) in small series. We screened 140 myeloma patients (36 patients with and 104 without BRONJ) for the presence of previously identified SNPs in PPARG and CYP2C8 genes. All the patients received exclusively zolendronic acid (ZA) therapy and were followed prospectively for BRONJ. SNPs in both genes were associated with a higher risk of development of early BRONJ, occurring within less than 2 years of ZA therapy (59% vs. 16%, p =.022 for PPARG and 29% vs. 7%, p =.07 for CYP2C8) and a shorter time to develop BRONJ (59% versus 12%, p =.011 for PPARG and 29% versus 0% at 2 years, p =.037 for CYP2C8), independently of indices of poor oral hygiene. Thus, although preliminary, our data indicate that the presence of SNPs in PPARG and CYP2C8 genes may be associated with increased risk of early BRONJ. © 2017 Informa UK Limited, trading as Taylor & Francis Group."
}