@article{3086725,
    title = "Placental expression of PAPPA, PAPPA-2 and PLAC-1 in pregnacies is associated with FGR",
    author = "Sifakis, S. and Androutsopoulos, V.P. and Pontikaki, A. and Velegrakis, A. and Papaioannou, G.I. and Koukoura, O. and Spandidos, D.A. and Papantoniou, N.",
    journal = "Molecular Medicine Reports",
    year = "2018",
    volume = "17",
    number = "5",
    pages = "6435-6440",
    publisher = "Spandidos Publications",
    issn = "1791-3004",
    doi = "10.3892/mmr.2018.8721",
    keywords = "placenta protein;  placenta specific 1 protein;  pregnancy associated plasma protein A;  pregnancy associated plasma protein A2;  unclassified drug;  PAPPA2 protein, human;  PLAC1 protein, human;  placenta protein;  pregnancy associated plasma protein A, adult;  Article;  birth weight;  clinical article;  controlled study;  female;  gene expression;  human;  human tissue;  intrauterine growth retardation;  placenta tissue;  pregnancy;  biosynthesis;  gene expression regulation;  intrauterine growth retardation;  metabolism;  pathology;  placenta;  pregnancy, Adult;  Female;  Fetal Growth Retardation;  Gene Expression Regulation;  Humans;  Placenta;  Pregnancy;  Pregnancy Proteins;  Pregnancy-Associated Plasma Protein-A",
    abstract = "Fetal growth restriction (FGR) is a gynecological disorder of varying etiology. In the present study, an expression analysis of pregnancy-associated plasma protein A (PAPPA), pregnancy-associated plasma protein A2 (PAPPA2) and placenta-specific-1 (PLAC-1) was conducted in pregnancies with FGR and control pregnancies. Placental tissues were collected from pregnancies with FGR (n=16) and control pregnancies (n=16) and the expression of the genes of interest was examined by qPCR. The mean expression levels of PAPPA and PAPPA2 were significantly lower (P<0.001) in placental tissues from FGR pregnancies compared with tissues from healthy subjects, whereas the opposite pattern was observed for PLAC-1 (P<0.001). PAPPA and PLAC-1 expression in FGR and control subjects correlated with birth weight (P<0.001). The findings suggest a possible pathophysiological link between the development of FGR and the expression of PAPPA, PAPPA2 and PLAC-1. © 2018 Spandidos Publications. All rights reserved."
}