@article{3086993,
    title = "Thioredoxin-1, chemokine (C-X-C motif) ligand-9 and interferon-γ expression in the neoplastic cells and macrophages of Hodgkin lymphoma: clinicopathologic correlations and potential prognostic implications",
    author = "P. Vassilakopoulos, T. and Levidou, G. and Milionis, V. and Hartmann, S. and Lakiotaki, E. and Sepsa, A. and Thymara, I. and Ntailiani, P. and Spanou, K. and K. Angelopoulou, M. and P. Siakantaris, M. and Moschogiannis, M. and A. Pangalis, G. and Panayiotidis, P. and Konstantopoulos, K. and Patsouris, E. and Hansmann, M.-L. and Korkolopoulou, P.",
    journal = "Clinical Lymphoma Myeloma and Leukemia",
    year = "2017",
    volume = "58",
    number = "9",
    pages = "2227-2239",
    publisher = "Taylor and Francis Ltd.",
    doi = "10.1080/10428194.2017.1289520",
    keywords = "caspase 3;  CXCL9 chemokine;  cyclin D3;  DNA topoisomerase (ATP hydrolysing) A;  gamma interferon;  Ki 67 antigen;  latent membrane protein 1;  protein bcl 2;  thioredoxin 1;  vasculotropin;  CXCL9 chemokine;  CXCL9 protein, human;  gamma interferon;  thioredoxin, adolescent;  adult;  age;  aged;  angiogenesis;  apoptosis;  Article;  cancer cell;  cancer prognosis;  cancer recurrence;  cell proliferation;  classical Hodgkin lymphoma;  cytoplasm;  epithelioid cell;  erythrocyte sedimentation rate;  failure free survival;  female;  follow up;  histiocyte;  human;  human cell;  human tissue;  immunohistochemistry;  intracellular space;  leukocytosis;  macrophage;  major clinical study;  male;  nodular lymphocyte predominant Hodgkin lymphoma;  priority journal;  protein expression;  retrospective study;  tumor microenvironment;  tumor volume;  cancer staging;  gene expression;  genetics;  Hodgkin disease;  macrophage;  metabolism;  middle aged;  mortality;  pathology;  prognosis;  proportional hazards model;  young adult, Adolescent;  Adult;  Aged;  Chemokine CXCL9;  Female;  Gene Expression;  Histiocytes;  Hodgkin Disease;  Humans;  Immunohistochemistry;  Interferon-gamma;  Macrophages;  Male;  Middle Aged;  Neoplasm Staging;  Prognosis;  Proportional Hazards Models;  Thioredoxins;  Tumor Microenvironment;  Young Adult",
    abstract = "Expression of thioredoxin-1 (TXN) and CXCL9 is not restricted to THRLBCL macrophages, but may be observed in histiocytes and neoplastic (HRS) cells of EBV + mixed cellularity (MC) classical Hodgkin lymphoma (cHL) and nodular lymphocyte predominant HL. We aimed to validate and extend the above observations in 174 cHL patients evaluating the immunohistochemical expression of TXN, CXCL9 and IFN-γ. HRS-cell CXCL9 expression was higher in latent membrane protein-1 (LMP1)+, MC and Stage IV. TXN and CXCL9 expression by cHL histiocytes was more frequent in LMP1+, MC and older patients (only for CXCL9). TXN expression by HRS cells (≥80%) was independently associated with better failure-free survival. In conclusion, markers of TCHRLBCL histiocytes (TXN, CXCL9), as well as IFN-γ are also expressed by histiocyte subsets and neoplastic cells of cHL. The expression of some of them is more prominent in EBV + MC, but not restricted to this subtype. The prognostic implication of TXN needs further evaluation. © 2017 Informa UK Limited, trading as Taylor & Francis Group."
}