@article{3087149,
    title = "Depression in choroidal melanoma patients treated with proton beam radiotherapy",
    author = "Moschos, M.M. and Moustafa, G.A. and Lavaris, A. and Damaskos, C. and Laios, K. and Karathanou, E. and Ladas, D.S. and Asproudis, I. and Garmpis, N. and Kalogeropoulos, C.",
    journal = "ANTICANCER RESEARCH",
    year = "2018",
    volume = "38",
    number = "5",
    pages = "3055-3061",
    publisher = "International Institute of Anticancer Research",
    issn = "0250-1291",
    doi = "10.21873/anticanres.12562",
    keywords = "adult;  Article;  best corrected visual acuity;  cancer radiotherapy;  choroid melanoma;  clinical article;  controlled study;  cross-sectional study;  depression;  disease severity;  female;  human;  male;  Patient Health Questionnaire 9;  priority journal;  proton therapy;  Zung Self Rating Depression Scale;  aged;  choroid tumor;  depression;  melanoma;  middle aged;  proton therapy;  psychology;  uvea tumor, Adult;  Aged;  Choroid Neoplasms;  Cross-Sectional Studies;  Depression;  Female;  Humans;  Male;  Melanoma;  Middle Aged;  Proton Therapy;  Uveal Neoplasms",
    abstract = "Aim: To determine depression in patients with choroidal melanoma (CM) treated with proton beam radiotherapy. Patients and Methods: This was a cross-sectional study including 50 patients with CM (50% males, mean age=49.88±6.34 years) and 46 age- and sex-matched healthy controls (52% males, mean age=48.60±8.05 years). Participants completed the Patient Health Questionnaire-9 (PHQ-9) and the Zung Self-Rating Depression Scale (SDS) questionnaires. Results: There was a considerable difference in visual acuity as logarithm of the minimum angle of resolution (logMAR) between the patient and control groups (1.16±0.97 and 0.04±0.05 logMAR, respectively, p<0.0001). Both PHQ-9 and SDS scores differed significantly between the two groups (10.18±4.68 and 8.07±4.90, p=0.04; and 47.94±12.56 and 39.91±8.80, p=0.004, respectively). Scores appeared to be positively correlated with logMAR visual acuity (Spearman rho=0.700, p<0.0001 for PHQ-9; and 0.767, p<0.0001 for SDS), and they were also correlated to each other (Spearman rho=0.759, p<0.0001). Conclusion: Patients with CM having undergone proton beam therapy seem to be more depressed compared to a sample of healthy individuals, and the level of depression is correlated with their visual acuity. © 2018 International Institute of Anticancer Research. All rights reserved."
}