@article{3087607,
    title = "Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer",
    author = "Childs, E.J. and Mocci, E. and Campa, D. and Bracci, P.M. and Gallinger, S. and Goggins, M. and Li, D. and Neale, R.E. and Olson, S.H. and Scelo, G. and Amundadottir, L.T. and Bamlet, W.R. and Bijlsma, M.F. and Blackford, A. and Borges, M. and Brennan, P. and Brenner, H. and Bueno-De-Mesquita, H.B. and Canzian, F. and Capurso, G. and Cavestro, G.M. and Chaffee, K.G. and Chanock, S.J. and Cleary, S.P. and Cotterchio, M. and Foretova, L. and Fuchs, C. and Funel, N. and Gazouli, M. and Hassan, M. and Herman, J.M. and Holcatova, I. and Holly, E.A. and Hoover, R.N. and Hung, R.J. and Janout, V. and Key, T.J. and Kupcinskas, J. and Kurtz, R.C. and Landi, S. and Lu, L. and Malecka-Panas, E. and Mambrini, A. and Mohelnikova-Duchonova, B. and Neoptolemos, J.P. and Oberg, A.L. and Orlow, I. and Pasquali, C. and Pezzilli, R. and Rizzato, C. and Saldia, A. and Scarpa, A. and Stolzenberg-Solomon, R.Z. and Strobel, O. and Tavano, F. and Vashist, Y.K. and Vodicka, P. and Wolpin, B.M. and Yu, H. and Petersen, G.M. and Risch, H.A. and Klein, A.P.",
    journal = "Nature Genetics",
    year = "2015",
    volume = "47",
    number = "8",
    pages = "911-916",
    publisher = "Nature Publishing Group",
    issn = "1061-4036, 1546-1718",
    doi = "10.1038/ng.3341",
    keywords = "E1A associated p300 protein;  hepatocyte nuclear factor 1;  hepatocyte nuclear factor 3alpha;  hepatocyte nuclear factor 3beta;  protein;  RAD21 protein;  unclassified drug, Article;  cancer risk;  controlled study;  gene linkage disequilibrium;  gene locus;  genetic association;  genetic susceptibility;  genetic variability;  genotype;  human;  major clinical study;  pancreas adenocarcinoma;  pancreas cancer;  phenotype;  phenotypic variation;  priority journal;  quantitative trait locus;  single nucleotide polymorphism;  smoking;  tissues;  aged;  Australia;  chromosome 17;  chromosome 2;  chromosome 3;  chromosome 7;  clinical trial;  Europe;  female;  gene frequency;  genetic predisposition;  genetics;  male;  middle aged;  multicenter study;  North America;  pancreas tumor;  procedures;  risk factor;  single nucleotide polymorphism, Aged;  Australia;  Chromosomes, Human, Pair 17;  Chromosomes, Human, Pair 2;  Chromosomes, Human, Pair 3;  Chromosomes, Human, Pair 7;  Europe;  Female;  Gene Frequency;  Genetic Loci;  Genetic Predisposition to Disease;  Genome-Wide Association Study;  Genotype;  Humans;  Male;  Middle Aged;  North America;  Pancreatic Neoplasms;  Polymorphism, Single Nucleotide;  Risk Factors",
    abstract = "Pancreatic cancer is the fourth leading cause of cancer death in the developed world. Both inherited high-penetrance mutations in BRCA2 (ref. 2), ATM, PALB2 (ref. 4), BRCA1 (ref. 5), STK11 (ref. 6), CDKN2A and mismatch-repair genes and low-penetrance loci are associated with increased risk. To identify new risk loci, we performed a genome-wide association study on 9,925 pancreatic cancer cases and 11,569 controls, including 4,164 newly genotyped cases and 3,792 controls in 9 studies from North America, Central Europe and Australia. We identified three newly associated regions: 17q25.1 (LINC00673, rs11655237, odds ratio (OR) = 1.26, 95% confidence interval (CI) = 1.19-1.34, P = 1.42 × 10-14), 7p13 (SUGCT, rs17688601, OR = 0.88, 95% CI = 0.84-0.92, P = 1.41 × 10-8) and 3q29 (TP63, rs9854771, OR = 0.89, 95% CI = 0.85-0.93, P = 2.35 × 10-8). We detected significant association at 2p13.3 (ETAA1, rs1486134, OR = 1.14, 95% CI = 1.09-1.19, P = 3.36 × 10-9), a region with previous suggestive evidence in Han Chinese. We replicated previously reported associations at 9q34.2 (ABO), 13q22.1 (KLF5), 5p15.33 (TERT and CLPTM1), 13q12.2 (PDX1), 1q32.1 (NR5A2), 7q32.3 (LINC-PINT), 16q23.1 (BCAR1) and 22q12.1 (ZNRF3). Our study identifies new loci associated with pancreatic cancer risk. © 2015 Nature America, Inc. All rights reserved."
}