@article{3088110,
    title = "Using ancestry-informative markers to identify fine structure across 15 populations of European origin",
    author = "Huckins, L.M. and Boraska, V. and Franklin, C.S. and Floyd, J.A.B. and Southam, L. and Sullivan, P.F. and Bulik, C.M. and Collier, D.A. and Tyler-Smith, C. and Zeggini, E. and Tachmazidou, I. and Thornton, L.M. and William Rayner, N. and Klump, K.L. and Treasure, J. and Schmidt, U. and Tozzi, F. and Kiezebrink, K. and Hebebrand, J. and Gorwood, P. and Adan, R.A.H. and Kas, M.J.H. and Favaro, A. and Santonastaso, P. and Fernández-Aranda, F. and Gratacos, M. and Rybakowski, F. and Dmitrzak-Weglarz, M. and Kaprio, J. and Keski-Rahkonen, A. and Raevuori, A. and Van Furth, E.F. and Slof-Op t Landt, M.C.T. and Hudson, J.I. and Reichborn-Kjennerud, T. and Knudsen, G.P.S. and Monteleone, P. and Kaplan, A.S. and Karwautz, A. and Hakonarson, H. and Berrettini, W.H. and Guo, Y. and Li, D. and Schork, N.J. and Komaki, G. and Ando, T. and Inoko, H. and Esko, T. and Fischer, K. and Männik, K. and Metspalu, A. and Baker, J.H. and Cone, R.D. and Dackor, J. and DeSocio, J.E. and Hilliard, C.E. and O'Toole, J.K. and Pantel, J. and Szatkiewicz, J.P. and Taico, C. and Zerwas, S. and Trace, S.E. and Davis, O.S.P. and Helder, S. and Bühren, K. and Burghardt, R. and de Zwaan, M. and Egberts, K. and Ehrlich, S. and Herpertz-Dahlmann, B. and Herzog, W. and Imgart, H. and Scherag, S. and Zipfel, S. and Boni, C. and Ramoz, N. and Versini, A. and Brandys, M.K. and Danner, U.N. and de Kovel, C. and Hendriks, J. and Koeleman, B.P.C. and Ophoff, R.A. and Strengman, E. and van Elburg, A.A. and Bruson, A. and Clementi, M. and Degortes, D. and Forzan, M. and Tenconi, E. and Docampo, E. and Escaramís, G. and Jiménez-Murcia, S. and Lissowska, J. and Rajewski, A. and Szeszenia-Dabrowska, N. and Slopien, A. and Hauser, J. and Karhunen, L. and Meulenbelt, I. and Slagboom, P.E. and Tortorella, A. and Maj, M. and Dedoussis, G. and Dikeos, D. and Gonidakis, F. and Tziouvas, K. and Tsitsika, A. and Papezova, H. and Slachtova, L. and Martaskova, D. and Kennedy, J.L. and Levitan, R.D. and Yilmaz, Z. and Huemer, J. and Koubek, D. and Merl, E. and Wagner, G. and Lichtenstein, P. and Breen, G. and Cohen-Woods, S. and Farmer, A. and McGuffin, P. and Cichon, S. and Giegling, I. and Herms, S. and Rujescu, D. and Schreiber, S. and Wichmann, H.-E. and Dina, C. and Sladek, R. and Gambaro, G. and Soranzo, N. and Julia, A. and Marsal, S. and Rabionet, R. and Gaborieau, V. and Dick, D.M. and Palotie, A. and Ripatti, S. and Widén, E. and Andreassen, O.A. and Espeseth, T. and Lundervold, A. and Reinvang, I. and Steen, V.M. and Le Hellard, S. and Mattingsdal, M. and Ntalla, I. and Bencko, V. and Foretova, L. and Janout, V. and Navratilova, M. and Gallinger, S. and Pinto, D. and Scherer, S.W. and Aschauer, H. and Carlberg, L. and Schosser, A. and Alfredsson, L. and Ding, B. and Klareskog, L. and Padyukov, L. and Finan, C. and Kalsi, G. and Roberts, M. and Logan, D.W. and Peltonen, L. and Ritchie, G.R.S. and Courtet, P. and Guillame, S. and Jaussent, I. and Barrett, J.C. and Estivill, X. and Hinney, A. and Bulik, C.M. and McGinnis, R. and Sambrook, J. and Stephens, J. and Ouwehand, W.H. and McArdle, W.L. and Ring, S.M. and Strachan, D.P. and Alexander, G. and Conlon, P.J. and Dominiczak, A. and Anderson, C.A. and Hill, A. and Langford, C. and Lord, G. and Maxwell, A.P. and Morgan, L. and Sandford, R.N. and Sheerin, N. and Vannberg, F.O. and Blackburn, H. and Chen, W.-M. and Edkins, S. and Gillman, M. and Gray, E. and Hunt, S.E. and Onengut-Gumuscu, S. and Potter, S. and Rich, S.S. and Simpkin, D. and Whittaker, P.",
    journal = "European Journal of Human Genetics: EJHG",
    year = "2014",
    volume = "22",
    number = "10",
    pages = "1190-1200",
    publisher = "Nature Publishing Group",
    issn = "1018-4813, 1476-5438",
    doi = "10.1038/ejhg.2014.1",
    keywords = "Article;  bulimia;  Central European;  Eastern European;  eating disorder;  European;  female;  gene frequency;  genetic association;  genetic distance;  genetic similarity;  genetic variability;  genotype;  geographic distribution;  human;  k nearest neighbor;  Northern European;  population genetic structure;  population size;  population stratification;  principal component analysis;  priority journal;  anorexia nervosa;  Caucasian;  DNA microarray;  genetic association;  genetic marker;  genetics;  genotyping technique;  phylogeography;  population genetics;  procedures;  reproducibility;  sample size;  single nucleotide polymorphism, genetic marker, Anorexia Nervosa;  European Continental Ancestry Group;  Gene Frequency;  Genetic Markers;  Genetics, Population;  Genome-Wide Association Study;  Genotyping Techniques;  Humans;  Oligonucleotide Array Sequence Analysis;  Phylogeography;  Polymorphism, Single Nucleotide;  Principal Component Analysis;  Reproducibility of Results;  Sample Size",
    abstract = "The Wellcome Trust Case Control Consortium 3 anorexia nervosa genome-wide association scan includes 2907 cases from 15 different populations of European origin genotyped on the Illumina 670K chip. We compared methods for identifying population stratification, and suggest list of markers that may help to counter this problem. It is usual to identify population structure in such studies using only common variants with minor allele frequency (MAF) >5%; we find that this may result in highly informative SNPs being discarded, and suggest that instead all SNPs with MAF >1% may be used. We established informative axes of variation identified via principal component analysis and highlight important features of the genetic structure of diverse European-descent populations, some studied for the first time at this scale. Finally, we investigated the substructure within each of these 15 populations and identified SNPs that help capture hidden stratification. This work can provide information regarding the designing and interpretation of association results in the International Consortia. © 2014 Macmillan Publishers Limited All rights reserved."
}