@article{3088202,
    title = "In vivo effect of two first-line ART regimens on inflammatory mediators in male HIV patients",
    author = "Papakonstantinou, V.D. and Chini, M. and Mangafas, N. and Stamatakis, G.M. and Tsogas, N. and Tsoupras, A.B. and Psarra, K. and Fragopoulou, E. and Antonopoulou, S. and Gargalianos, P. and Demopoulos, C.A. and Lazanas, M.-C.",
    journal = "Lipids in Health and Disease",
    year = "2014",
    volume = "13",
    number = "1",
    publisher = "BioMed Central Ltd.",
    issn = "1476-511X",
    doi = "10.1186/1476-511X-13-90",
    keywords = "1 alkyl 2 acetylglycerophosphocholine esterase;  abacavir;  antiretrovirus agent;  efavirenz;  emtricitabine;  high density lipoprotein;  interleukin 10;  interleukin 12p70;  interleukin 1beta;  interleukin 6;  interleukin 8;  lamivudine;  low density lipoprotein;  tenofovir;  thrombocyte activating factor;  tumor necrosis factor alpha;  vasculotropin;  adenine;  anti human immunodeficiency virus agent;  benzoxazine derivative;  efavirenz;  interleukin 10;  interleukin 6;  interleukin 8;  lamivudine;  phosphonic acid derivative;  tenofovir;  thrombocyte activating factor;  tumor necrosis factor alpha, adult;  article;  cardiovascular risk;  cholesterol blood level;  clinical article;  enzyme activity;  enzyme linked immunosorbent assay;  human;  Human immunodeficiency virus infection;  in vivo study;  leukocyte;  male;  thrombocyte;  analogs and derivatives;  animal;  HIV Infections;  metabolism;  middle aged, Human immunodeficiency virus, Adenine;  Adult;  Animals;  Anti-HIV Agents;  Benzoxazines;  HIV Infections;  Humans;  Interleukin-10;  Interleukin-6;  Interleukin-8;  Lamivudine;  Male;  Middle Aged;  Organophosphonates;  Platelet Activating Factor;  Tumor Necrosis Factor-alpha",
    abstract = "Background: Persistent immune activation and inflammation are lying behind HIV-infection even in the setting of ART mediated viral suppression. The purpose of this study is to define the in vivo effect of two first-line ART regimens on certain inflammatory mediators in male HIV patients. Methods. Male, naive, HIV-infected volunteers were assigned either to tenofovir-DF/emtricitabine/ efavirenz (Group-T) or abacavir/lamivudine/efavirenz (Group-A). Platelet Activating Factor (PAF) levels and metabolic enzymes together with HIV-implicated cytokines (IL-1beta, IL-6, IL-8, IL-10, IL-12p70, TNFa) and VEGF were determined for a 12-month period. Differences within each group were determined by non-parametric Friedman and Wilcoxon test, while the differences between the groups were checked by ANOVA repeated measures. Results: Both ART regimens present pronounced effect on inflammatory mediators, resulting in decreased PAF levels and Lipoprotein-associated phospholipase A2 (Lp-PLA2) activity for tenofovir-containing regimen and same as baseline PAF levels with a peak though at the 3rd month as well as elevated Lp-PLA2 activity for abacavir-containing regimen. Conclusions: Studies regarding the effect of first-line ART regimens on inflammation may be beneficial in preventing chronic morbidities during HIV-treatment. From this point of view, the present study suggests an anti-inflammatory effect of tenofovir-containing ART, while the temporary increase of PAF levels in abacavir-containing ART may be the link between the reported cardiovascular risk and abacavir administration. © 2014 Papakonstantinou et al.; licensee BioMed Central Ltd."
}