@article{3088486,
    title = "Children and adolescents with type 1 diabetes mellitus have a sixfold greater risk for prolonged QTc interval",
    author = "Galli-Tsinopoulou, A. and Chatzidimitriou, A. and Kyrgios, I. and Rousso, I. and Varlamis, G. and Karavanaki, K.",
    journal = "Journal of Pediatric Endocrinology and Metabolism",
    year = "2014",
    volume = "27",
    number = "3-4",
    pages = "237-243",
    publisher = "Freund Publishing House Ltd",
    doi = "10.1515/jpem-2013-0193",
    keywords = "adolescent;  adolescent disease;  article;  autonomic dysfunction;  child;  childhood disease;  correlation analysis;  electrocardiogram;  female;  follow up;  human;  insulin dependent diabetes mellitus;  major clinical study;  male;  onset age;  QT prolongation;  risk assessment;  sex difference, Child;  Diabetes Mellitus, Type 1;  Electrocardiography;  Female;  Heart;  Humans;  Male;  Risk Factors;  Young Adult",
    abstract = "Background: QT-wave abnormalities have been detected in type 1 diabetes mellitus (T1DM). Prolongation of the heart rate corrected QT interval (QTc) has been associated with cardiovascular mortality. We evaluated how often QT/QTc abnormalities are present in youth with T1DM and if they are associated with disease parameters. Methods: Sixty-two T1DM youngsters and equal age- and gender-matched controls were studied. Demographic, anthropometric, and laboratory data were determined. QT was measured on a 12-lead resting electrocardiogram. QTc was calculated using Bazett's formula. Results: T1DM patients had significantly longer QT/QTc than controls, but significance disappeared after adjustment for confounders. Abnormally prolonged QTc≥440 ms was observed six times more frequently in those with T1DM. QT was correlated with age, age at disease onset, but not with glycated hemoglobin or diabetes duration; QTc was only correlated with pubertal stage. Conclusions: T1DM youths have a sixfold increased risk for QT/QTc prolongation and should have regular follow-up for cardiac autonomic dysfunction. © 2014 by Walter de Gruyter Berlin Boston 2014."
}