@article{3088806,
    title = "Polymorphisms of uridine glucuronosyltransferase gene and irinotecan toxicity: Low dose does not protect from toxicity",
    author = "Tziotou, M. and Kalotychou, V. and Ntokou, A. and Tzanetea, R. and Armenis, I. and Varsou, M. and Konstantopoulos, K. and Tsavaris, N. and Rombos, Y.",
    journal = "ecancermedicalscience",
    year = "2014",
    volume = "8",
    number = "1",
    publisher = "European Institute of Oncology",
    issn = "1754-6605",
    doi = "10.3332/ecancer.2014.428",
    keywords = "DNA;  fluorouracil;  folinic acid;  glucuronosyltransferase 1A1;  glucuronosyltransferase 1A7;  irinotecan;  uridine, adult;  aged;  anemia;  article;  blood sampling;  clinical article;  diarrhea;  drug dose reduction;  drug withdrawal;  exon;  febrile neutropenia;  female;  gene;  genetic polymorphism;  genotype;  Greece;  human;  laboratory test;  leukopenia;  low drug dose;  male;  metastatic colorectal cancer;  middle aged;  nausea;  neutropenia;  physical examination;  promoter region;  thrombocytopenia;  vomiting",
    abstract = "Uridine glucuronosyltransferase (UGT) gene polymorphisms have been linked to irinotecan toxicity. Our purpose was to study the association between UGT1A1*28, UGT1A7*2, and UGT1A7*3 polymorphisms and irinotecan toxicity in Greek patients receiving low-dose weekly irinotecan. Blood samples were collected for 46 patients. DNA was extracted and UGT1A1 promoter and UGT1A7 exon 1 genotyping was carried out. Laboratory tests and physical examination were performed on regular basis for the assessment of toxicity. UGT1A1*28 was significantly correlated with both haematologic and non-haematologic toxicity. Moreover, patients carrying UGT1A7 polymorphisms had significant incidence of toxicity. To conclude, UGT polymorphisms play a role in the toxicity of irinotecan, even if the drug is administered in low doses. The genotyping test may be a useful tool for the management of patients who are going to receive irinotecan. © the authors; licensee ecancermedicalscience."
}