@article{3089658,
    title = "Inflammatory markers in coronary artery disease",
    author = "Ikonomidis, I. and Michalakeas, C.A. and Parissis, J. and Paraskevaidis, I. and Ntai, K. and Papadakis, I. and Anastasiou-Nana, M. and Lekakis, J.",
    journal = "BioFactors",
    year = "2012",
    volume = "38",
    number = "5",
    pages = "320-328",
    issn = "0951-6433, 1872-8081",
    doi = "10.1002/biof.1024",
    keywords = "biological marker;  C reactive protein;  darapladib;  granulocyte macrophage colony stimulating factor;  hydroxymethylglutaryl coenzyme A reductase inhibitor;  immunoglobulin enhancer binding protein;  interleukin 18;  interleukin 1beta;  interleukin 6;  monocyte chemotactic protein 1;  nitric oxide synthase;  osteoprotegerin;  prednisolone;  recombinant interleukin 1 receptor blocking agent;  serotonin uptake inhibitor;  tumor necrosis factor alpha, atherosclerosis;  cardiovascular risk;  chlamydial pneumonia;  coronary artery disease;  cytokine production;  depression;  disease course;  drug mechanism;  human;  hyperlipidemia;  priority journal;  prognosis;  protein blood level;  protein expression;  review;  rheumatoid arthritis, 1-Alkyl-2-acetylglycerophosphocholine Esterase;  Anti-Inflammatory Agents;  Atherosclerosis;  Biological Markers;  C-Reactive Protein;  Coronary Artery Disease;  Coronary Vessels;  Cytokines;  Disease Progression;  Humans;  Inflammation;  Leukocyte Count;  Leukocytes;  Nitric Oxide Synthase Type II",
    abstract = "Coronary artery disease (CAD) is one of the most common manifestations of atherosclerosis. Inflammation is considered one of the major processes that contribute to atherogenesis. Inflammation plays an important role not only on the initiation and progression of atherosclerosis but also on plaque rupture, an event that leads to acute vascular events. Various biomarkers express different pathways and pathophysiologic mechanisms of cardiovascular disease, and inflammatory biomarkers express different parts of the atherogenic process, regarding the initiation and progression of atherosclerosis or the destabilization of the atherosclerotic plaque. Therefore, inflammatory biomarkers may prove to be useful in the detection, staging, and prognosis of patients with CAD. Furthermore, the fact that inflammatory processes are essential steps in the course of the disease offers future therapeutic targets for the interruption of the atherogenic process or for the management of acute events. © 2012 International Union of Biochemistry and Molecular Biology, Inc."
}