@article{3089696,
    title = "The association of circulating adiponectin levels with pancreatic cancer risk: A study within the prospective EPIC cohort",
    author = "Grote, V.A. and Rohrmann, S. and Dossus, L. and Nieters, A. and Halkjær, J. and Tjønneland, A. and Overvad, K. and Stegger, J. and Chabbert-Buffet, N. and Boutron-Ruault, M.-C. and Clavel-Chapelon, F. and Teucher, B. and Becker, S. and Montonen, J. and Boeing, H. and Trichopoulou, A. and Lagiou, P. and Trichopoulos, D. and Palli, D. and Sieri, S. and Tumino, R. and Vineis, P. and Mattiello, A. and Argüelles, M. and Duell, E.J. and Molina-Montes, E. and Larrañaga, N. and Chirlaque, M.-D. and Gurrea, A.B. and Jeurnink, S.M. and Peeters, P.H.M. and Ye, W. and Sund, M. and Lindkvist, B. and Johansen, D. and Khaw, K.-T. and Wareham, N. and Crowe, F.L. and Romieu, I. and Rinaldi, S. and Jenab, M. and Romaguera, D. and Michaud, D.S. and Riboli, E. and Bas Bueno-De-Mesquita, H. and Kaaks, R.",
    journal = "International Journal  of Cancer",
    year = "2012",
    volume = "130",
    number = "10",
    pages = "2428-2437",
    issn = "0020-7136",
    doi = "10.1002/ijc.26244",
    keywords = "adiponectin, adult;  aged;  article;  blood analysis;  cancer risk;  carcinogenesis;  case control study;  cohort analysis;  controlled study;  disease association;  female;  histopathology;  human;  human tissue;  immunoassay;  major clinical study;  male;  pancreas cancer;  priority journal;  prospective study;  protein blood level;  protein function;  risk reduction;  sex difference;  smoking, Adiponectin;  Adult;  Aged;  Aged, 80 and over;  Body Mass Index;  Case-Control Studies;  Diabetes Mellitus, Type 2;  Female;  Humans;  Male;  Middle Aged;  Pancreatic Neoplasms;  Risk;  Smoking",
    abstract = "Excess body weight and type 2 diabetes mellitus, risk factors of pancreatic cancer, are characterized by decreased levels of adiponectin. In addition to anti-inflammatory and anti-proliferative actions, adiponectin has an important role in regulating glucose metabolism, i.e., decreasing circulating blood glucose levels. Prospectively, hyperglycemia has been associated with risk of pancreatic cancer. The aim of this study was to investigate the association of pre-diagnostic adiponectin levels with pancreatic cancer risk. We conducted a case-control study nested within European Prospective Investigation into Cancer and Nutrition. Blood samples of 452 pancreatic cancer cases and 452 individually matched controls were analyzed by immunoassays. Multivariate conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). Overall, adiponectin showed no association with pancreas cancer risk; however, among never smokers, higher circulating levels of adiponectin were associated with a reduction in pancreatic cancer risk (OR = 0.44 [95% CI 0.23-0.82] for highest vs. lowest quartile), whereas among current smokers there was no significant association (OR = 1.59 [95% CI 0.67-3.76] for highest vs. lowest quartile; p-trend = 0.530; p-interaction = 0.309). In our study, lower adiponectin concentrations may be associated with the development of pancreatic cancer among never smokers, whereas the only other prospective study being conducted so far showed a decrease in risk among male smokers. Therefore, further studies are needed to clarify the role of adiponectin in pancreatic cancer development. © 2011 UICC."
}