@article{3090027,
    title = "Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk",
    author = "Campa, D. and McKay, J. and Sinilnikova, O. and Hüsing, A. and Vogel, U. and Hansen, R.D. and Overvad, K. and Witt, P.M. and Clavel-Chapelon, F. and Boutron-Ruault, M.-C. and Chajes, V. and Rohrmann, S. and Chang-Claude, J. and Boeing, H. and Fisher, E. and Trichopoulou, A. and Trichopoulos, D. and Palli, D. and Villarini, A. and Sacerdote, C. and Mattiello, A. and Tumino, R. and Peeters, P.H.M. and Van Gils, C.H. and Bas Bueno-De-Mesquita, H. and Lund, E. and Chirlaque, M.D. and Sala, N. and Suarez, L.R. and Barricarte, A. and Dorronsoro, M. and Sánchez, M.-J. and Lenner, P. and Hallmans, G. and Tsilidis, K. and Bingham, S. and Khaw, K.-T. and Gallo, V. and Norat, T. and Riboli, E. and Rinaldi, S. and Lenoir, G. and Tavtigian, S.V. and Canzian, F. and Kaaks, R.",
    journal = "Breast Cancer Research and Treatment",
    year = "2009",
    volume = "118",
    number = "3",
    pages = "565-574",
    issn = "0167-6806, 1573-7217",
    doi = "10.1007/s10549-009-0347-8",
    keywords = "carbohydrate response element binding protein;  Fas antigen;  fatty acid;  fatty acid synthase;  nucleic acid binding protein;  sterol regulatory element binding protein;  unclassified drug, adult;  aged;  article;  body mass;  breast cancer;  cancer risk;  cancer susceptibility;  controlled study;  fatty acid synthesis;  female;  follow up;  gene sequence;  genetic association;  genetic variability;  genotype;  human;  major clinical study;  male;  menopause;  priority journal;  single nucleotide polymorphism, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors;  Body Mass Index;  Breast Neoplasms;  Fatty Acid Synthetase Complex, Type I;  Female;  Genetic Predisposition to Disease;  Genetic Variation;  Humans;  Obesity;  Polymerase Chain Reaction;  Polymorphism, Single Nucleotide;  Risk Factors;  Sterol Regulatory Element Binding Protein 1",
    abstract = "Fatty acid synthase (FAS) is the major enzyme of lipogenesis. It catalyzes the NADPH-dependent condensation of acetyl-CoA and malonyl-CoA to produce palmitic acid. Transcription of the FAS gene is controlled synergistically by the transcription factors ChREBP (carbohydrate response element-binding protein), which is induced by glucose, and SREBP-1 (sterol response element-binding protein-1), which is stimulated by insulin through the PI3K/Akt signal transduction pathway. We investigated whether the genetic variability of the genes encoding for ChREBP, SREBP and FAS (respectively, MLXIPL, SREBF1 and FASN) is related to breast cancer risk and body-mass index (BMI) by studying 1,294 breast cancer cases and 2,452 controls from the European Prospective Investigation on Cancer (EPIC). We resequenced the FAS gene and combined information of SNPs found by resequencing and SNPs from public databases. Using a tagging approach and selecting 20 SNPs, we covered all the common genetic variation of these genes. In this study we were not able to find any statistically significant association between the SNPs in the FAS, ChREBP and SREPB-1 genes and an increased risk of breast cancer overall and by subgroups of age, menopausal status, hormone replacement therapy (HRT) use or BMI. On the other hand, we found that two SNPs in FASN were associated with BMI. © 2009 Springer Science+Business Media, LLC."
}