@article{3090357,
    title = "Transcripts of PTTG and growth factors bFGF and IGF-1 are correlated in pituitary adenomas",
    author = "Chamaon, K. and Kanakis, D. and Mawrin, C. and Dietzmann, K. and Kirches, E.",
    journal = "Experimental and Clinical Endocrinology and Diabetes",
    year = "2010",
    volume = "118",
    number = "2",
    pages = "121-126",
    doi = "10.1055/s-0029-1215588",
    keywords = "basic fibroblast growth factor;  complementary DNA;  messenger RNA;  RNA;  securin;  somatomedin C, article;  astrocytoma;  breast cancer;  calculation;  cancer cell;  controlled study;  frozen section;  gene control;  genetic transcription;  human;  human cell;  hypophysis adenoma;  immunohistochemistry;  major clinical study;  priority journal;  reverse transcription polymerase chain reaction, Adenoma;  Fibroblast Growth Factor 2;  Gene Expression Regulation, Neoplastic;  Humans;  Insulin-Like Growth Factor I;  Neoplasm Proteins;  Pituitary Gland;  Pituitary Neoplasms;  Reverse Transcriptase Polymerase Chain Reaction;  RNA, Messenger",
    abstract = "The reasons for the increase of pituitary tumor-transforming gene (PTTG) transcripts in about 90% of pituitary adenomas are still not fully understood, although upregulation by basic fibroblast growth factor (bFGF) has been discussed as a potential cause. A possible influence of the Insulin like Growth Factor 1 (IGF-1) might be of interest, since this protein is also synthesized in most pituitary adenomas. Moreover, the principal regulation of the PTTG gene by IGF-1 and Insulin has been demonstrated in astrocytoma and breast cancer cells. We analyzed a large group (103 patients) of unselected clinical pituitary adenoma samples. From total RNA of frozen tumor samples (all subtypes) cDNA (complementary DNA) was synthesized and transcripts of PTTG, bFGF, IGF-1 were measured by Real-Time-PCR. Not only mRNA (messenger RNA) levels of bFGF, but also of IGF-1, correlated strongly with PTTG transcripts. This result was obtained, when all pituitary adenoma samples were included in the statistical calculations, irrespective of their subclassification. Our study suggests a connection between PTTG and IGF-1 in pituitary adenomas. © J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart New York."
}