@article{3090857,
    title = "Analysis of somatic hypermutations of immunoglobulin gene rearrangements in childhood acute lymphoblastic leukemia",
    author = "Braoudaki, M. and Katsibardi, K. and Giudicelli, V. and Karamolegou, K. and Papathanassiou, C. and Lefranc, M.-P. and Tzortzatou-Stathopoulou, F.",
    journal = "Cancer Investigation",
    year = "2011",
    volume = "29",
    number = "5",
    pages = "360-364",
    issn = "0735-7907, 1532-4192",
    doi = "10.3109/07357907.2011.584587",
    keywords = "acute lymphoblastic leukemia;  article;  cancer diagnosis;  cancer relapse;  childhood disease;  controlled study;  gene frequency;  gene rearrangement;  gene sequence;  human;  human tissue;  immunoglobulin gene;  major clinical study;  mutational analysis;  priority journal;  sequence analysis;  somatic hypermutation, Biopsy;  Bone Marrow Examination;  DNA Mutational Analysis;  Gene Rearrangement, B-Lymphocyte;  Genes, Immunoglobulin;  Greece;  Humans;  Immunoglobulin Variable Region;  Precursor Cell Lymphoblastic Leukemia-Lymphoma;  Recurrence;  Somatic Hypermutation, Immunoglobulin",
    abstract = "The current study investigated the presence, frequency, and status of somatic hypermutations as well as their role in children with B lineage ALL. The obtained sequences were analyzed using IMGT/V-QUEST. Totally, 150 IGH sequences were evaluated; 139 from the 111 patients at the time of diagnosis and 11 from 8/111 patients at the time of relapse. The findings of the current report revealed the presence of somatically mutated V genes in childhood B lineage ALL. A higher frequency of somatic hypermutations was noted in unproductive rearrangements and was generally attributed to nucleotide mutation type, region, and IGHV gene subgroup biases. © 2011 Informa Healthcare USA, Inc."
}