@article{3091915,
    title = "Multicenter linkage study of schizophrenia loci on chromosome 22q",
    author = "Mowry, BJ and Holmans, PA and Pulver, AE and Gejman, PV and Riley, B and and Williams, NM and Laurent, C and Schwab, SG and Wildenauer, DB and and Bauche, S and Owen, MJ and Wormley, B and Sanders, AR and Nestadt, G and and Liang, KY and Duan, J and Ribble, R and Norton, N and Soubigou, S and and Maier, W and Ewen-White, KR and deMarchi, N and Carpenter, B and Walsh, and D and Williams, H and Jay, M and Albus, M and Nertney, DA and and Papadimitriou, G and O'Neill, A and O'Donovan, MC and Deleuze, JF and and Lerer, FB and Dikeos, D and Kendler, KS and Mallet, J and Silverman, JM and and Crowe, RR and Levinson, DF",
    journal = "Journal of Molecular Psychiatry",
    year = "2004",
    volume = "9",
    number = "8",
    pages = "784-795",
    publisher = "Nature Publishing Group",
    issn = "2049-9256",
    doi = "10.1038/sj.mp.4001481",
    keywords = "linkage (genetics); chromosomes, human, pair 22; schizophrenia;
genetics, molecular; genetics, medical",
    abstract = "The hypothesis of the existence of one or more schizophrenia
susceptibility loci on chromosome 22q is supported by reports of genetic
linkage and association, meta-analyses of linkage, and the observation
of elevated risk for psychosis in people with velocardiofacial syndrome,
caused by 22q11 microdeletions. We tested this hypothesis by evaluating
10 microsatellite markers spanning 22q in a multicenter sample of 779
pedigrees. We also incorporated age at onset and sex into the analysis
as covariates. No significant evidence for linkage to schizophrenia or
for linkage associated with earlier age at onset, gender, or
heterogeneity across sites was observed. We interpret these findings to
mean that the population-wide effects of putative 22q schizophrenia
susceptibility loci are too weak to detect with linkage analysis even in
large samples."
}