@article{3093721, title = "The intrauterine origin of male breast cancer: a birth order study in Denmark", author = "Sorensen, HT and Olsen, ML and Mellemkjaer, L and Lagiou, P and Olsen, and JH and Olsen, J", journal = "European Journal of Cancer Prevention: The Official Journal of the European Cancer Prevention Organisation (ECP)", year = "2005", volume = "14", number = "2", pages = "185-186", publisher = "Lippincott, Williams & Wilkins", issn = "0959-8278", doi = "10.1097/00008469-200504000-00016", keywords = "birth order; case-control; in utero; male breast cancer", abstract = "First pregnancies are known to have higher oestrogen levels than later ones and first-born women are at increased breast cancer risk compared with later-born women. We hypothesized that a birth order effect might be even more evident in male breast cancer patients, in whom oestrogens in adult life are generally low. In a population-based study in Denmark involving 77 male breast cancer patients and 288 population controls, first-born men compared with later-born men had a relative risk of 1.71 for the disease (95% confidence interval (Cl) 1.00-2.92). This result is in line with that seen in female breast cancer cases and indicates that male breast cancer may have roots in the intrauterine life, oestrogens being a likely mediator. (c) 2005 Lippincott Williams & Wilkins." }