@article{3094073,
    title = "N-6 polynsaturated fatty acids confer hemodynamic stability in an
experimental model of multiple trauma",
    author = "Efstathopoulos, N and Bathrellos, E and Giamarellos-Bourboulis, EJ and and Lazarettos, J and Papalois, A and Grecka, P and Nikolaou, V",
    journal = "Prostaglandins, Leukotrienes and Essential Fatty Acids",
    year = "2005",
    volume = "72",
    number = "5",
    pages = "357-362",
    publisher = "Elsevier Sci Ltd, Exeter, United Kingdom",
    issn = "0952-3278",
    doi = "10.1016/j.plefa.2005.02.001",
    abstract = "Immunonutrition with diets enriched in polyunsaturated fatty acids
(PUFAs) are becoming mandatory for multiple trauma patients. Solutions
containing single n-6 PUFAs were administered intravenously in an
experimental model of trauma. Thirty-five rabbits were studied; 13
controls; 10 administered gamma-linolenic acid (GLA) 30 min after
fracture of the right femor; and 12 arachidonic acid (AA). Systolic,
diastolic and mean arterial pressures and heart rate were recorded;
serum levels of tumor necrosis factor-alpha (TNF alpha), malondialdehyde
(MDA) and nitrate were estimated before and after therapy. Mean survival
of controls, of animals treated with GLA and of animals treated with AA
was 0.80, 1.41 and 3.60 days, respectively. Administration of PUFAs
induced higher levels of blood pressure; that of AA decreased serum TNF
alpha and tissue bacterial load compared to controls. Intravenous
administration of n-6 PUFAs conferred hemodynamic stability and
increased survival in a model of trauma rendering further research
mandatory. (c) 2005 Elsevier Ltd. All rights reserved."
}