@article{3095511,
    title = "Acute myelogenous leukemia with tetrasomy 8 is a disease with a poor prognosis",
    author = "Tsirigotis, P. and Papageorgiou, S. and Abatzis, D. and Athanatou, S. and Girkas, C. and Pappa, V. and Pangalos, C. and Papageorgiou, E. and Dervenoulas, J. and Raptis, S.",
    journal = "CANCER GENETICS AND CYTOGENETICS",
    year = "2005",
    volume = "161",
    number = "1",
    pages = "78-81",
    issn = "0165-4608",
    doi = "10.1016/j.cancergencyto.2004.12.016",
    keywords = "cytarabine;  etoposide;  idarubicin, acute granulocytic leukemia;  adult;  article;  bone marrow biopsy;  cancer chemotherapy;  cancer cytodiagnosis;  cancer prevention;  case report;  chromosome 8;  female;  flow cytometry;  human;  priority journal;  prognosis;  recurrent cancer;  relapse;  salvage therapy;  tetrasomy, Adult;  Aneuploidy;  Chromosome Aberrations;  Chromosomes, Human, Pair 8;  Female;  Humans;  In Situ Hybridization, Fluorescence;  Karyotyping;  Leukemia, Myelocytic, Acute;  Prognosis",
    abstract = "Tetrasomy 8 is an extremely rare chromosome abnormality, one that has been reported in only a few cases with myeloid malignancies. The majority of reported cases consist of acute myelogenous leukemias (AML) of monocytic lineage. In slightly more than half of the patients, tetrasomy 8 was the single cytogenetic abnormality. Fluorescence in situ hybridization revealed tetrasomy 8 and trisomy 8 concurrently in all but one of the bone marrow samples. The clonal relationship between trisomy 8 and tetrasomy 8 in these cases remains to be clarified. Patients with tetrasomy 8 have a poor prognosis, and only 1 out of 33 patients was free of disease 3 years after autologous bone marrow transplantation. Here, we report the case of a 25-year-old female patient with monocytic leukemia and tetrasomy 8. © 2005 Elsevier Inc. All rights reserved."
}