@article{3095717,
    title = "Changes in leptin serum levels in HIV-infected children receiving highly active antiretroviral therapy",
    author = "Papaevangelou, V. and Papassotiriou, I. and Vounatsou, M. and Chrousos, G. and Theodoridou, M.",
    journal = "Scandinavian Journal of Clinical and Laboratory Investigation",
    year = "2007",
    volume = "67",
    number = "3",
    pages = "291-296",
    issn = "0036-5513, 1502-7686",
    doi = "10.1080/00365510601045062",
    keywords = "leptin;  proteinase inhibitor;  RNA directed DNA polymerase inhibitor, article;  blood level;  blood sampling;  body composition;  body mass;  child;  clinical article;  controlled study;  correlation analysis;  female;  follow up;  highly active antiretroviral therapy;  HIV associated lipodystrophy;  human;  Human immunodeficiency virus infected patient;  Human immunodeficiency virus infection;  male;  nutritional status;  priority journal;  protein blood level, Acquired Immunodeficiency Syndrome;  Adult;  Anti-HIV Agents;  Antiretroviral Therapy, Highly Active;  Body Mass Index;  CD4 Lymphocyte Count;  CD4-Positive T-Lymphocytes;  Child;  Child, Preschool;  Cohort Studies;  Female;  HIV;  HIV-Associated Lipodystrophy Syndrome;  Humans;  Infant;  Leptin;  Male;  Nutritional Status;  Retrospective Studies;  Statistics, Nonparametric;  Viral Load",
    abstract = "Highly active antiretroviral therapy (HAART) has significantly improved the prognosis of HIV(+) in children. Human immunodeficiency-associated lipodystrophy syndrome (HALS) is a side effect of HAART seen predominantly in adults and less often in children. Leptin is a protein thought to play an important role in body composition and has been shown to have immunomodulatory effects. We retrospectively studied serum levels of leptin in a cohort of eight HIV-infected children followed prospectively before and during HAART and investigated whether there is a correlation of these levels with the clinical, immunological, viral or nutritional changes observed during treatment in these children. None of our children developed HALS. In this small cohort of children, we found that serum leptin levels were appropriate to the nutritional status of the patient and that leptin/BMI increased in patients who responded to HAART. In conclusion, in HIV(+) children during HAART, leptin levels are related to the nutritional status of the child. © 2007 Taylor & Francis."
}