@article{3095773,
    title = "Association of mild and severely unstable α chain variants: The first observation of a compound heterozygote with Hb Setif [α94(G1)Asp→Tyr (α2)] and Hb Agrinio [α29(B10)Leu→Pro (α2)] in a Greek family",
    author = "Douna, V. and Papassotiriou, I. and Stamoulakatou, A. and Metaxotou-Mavrommati, A. and Kanavakis, E. and Traeger-Synodinos, J.",
    journal = "Hemoglobin:  Interrnational Journal for Hemoglobin Research",
    year = "2008",
    volume = "32",
    number = "6",
    pages = "592-595",
    issn = "0363-0269",
    doi = "10.1080/03630260802507964",
    keywords = "aspartic acid;  hemoglobin A2;  hemoglobin alpha chain;  leucine;  proline;  tyrosine, anamnesis;  anemia;  article;  blood analysis;  case report;  codon;  DNA determination;  electrophoresis;  family history;  genetic variability;  Greece;  growth, development and aging;  heterozygote;  human;  laboratory test;  preschool child, Adult;  alpha-Globins;  Amino Acid Substitution;  Anemia;  Aspartic Acid;  Child;  Child, Preschool;  Female;  Greece;  Hemoglobins, Abnormal;  Heterozygote;  Humans;  Leucine;  Male;  Middle Aged;  Proline;  Tyrosine",
    abstract = "Hb Setif is a relatively rare, mildly unstable α2-globin hemoglobin (Hb) variant first described in an Algerian family, and subsequently in various populations of the Mediterranean region and the Middle East. Hb Agrinio is a highly unstable variant, classified as a nondeletional α-thalassemia (α-thal) mutation, which, to date, has only been described in Greece and Cyprus. We report here the clinical and hematological findings in a case of Greek origin, who, following DNA analysis, was characterized with the unusual interaction of the Hb Setif α2-globin gene variant at codon 94 variant, in trans to Hb Agrinio, an α2-globin gene variant at codon 29. The compound heterozygote proband had only mild anemia with no transfusion requirements and with normal growth and development. We also report the laboratory findings in members of his family, highlighting diagnostic difficulties in the absence of molecular analysis. Copyright © Informa Healthcare USA, Inc."
}