@article{3096190,
    title = "Apolipoprotein E polymorphism in the Greek population",
    author = "Sklavounou, E. and Economou-Petersen, E. and Karadima, G. and Panas, M. and Avramopoulos, D. and Varsou, A. and Vassilopoulos, D. and Petersen, M.B.",
    journal = "Application of Clinical Genetics",
    year = "1997",
    volume = "52",
    number = "4",
    pages = "216-218",
    publisher = "Wiley-Blackwell Publishing Ltd",
    doi = "10.1111/j.1399-0004.1997.tb02550.x",
    keywords = "apolipoprotein E;  cholesterol, adult;  allele;  Alzheimer disease;  article;  atherosclerosis;  blood donor;  cardiovascular disease;  Chinese;  cholesterol blood level;  chromosome 19;  DNA polymorphism;  female;  gene frequency;  gene location;  genetic association;  Greece;  human;  human cell;  longevity;  major clinical study;  male;  normal human;  population genetics;  priority journal",
    abstract = "The APOE gene is located on chromosome 19, and the three common alleles are designated ε2, ε3, and ε4. The ε4 allele is associated with increased plasma cholesterol, atherosclerosis and cardiovascular disease, Alzheimer's disease, and decreased longevity. The objective of the present study was to estimate the distribution of APOE alleles in the Greek population by DNA analysis. The material consisted of 216 voluntary, healthy Creek blood donors (146 males/70 females). The APOE allele frequencies were ε2: 5.3%, ε3: 88.2%, ε4: 6.5%. The ε4 allele frequency of 6.5% in the Greek population is, together with the frequency in the Chinese population, among the lowest in the world."
}