@article{3096648,
    title = "Moc-31, fibronectin and CEA in the differential diagnosis of malignant effusions: An immunocytochemical study",
    author = "Athanassiadou, P. and Gonidi, M. and Liossi, A. and Petrakakou, E. and Nakopoulou, L. and Zerva, C. and Athanassiades, P.",
    journal = "Pathology and Oncology Research",
    year = "2000",
    volume = "6",
    number = "2",
    pages = "100-103",
    publisher = "Kluwer Academic Publishers",
    issn = "1219-4956",
    doi = "10.1007/BF03032357",
    keywords = "antibody;  carcinoembryonic antigen;  fibronectin;  membrane protein, article;  controlled study;  effusion;  human;  immunocytochemistry;  major clinical study;  malignant neoplastic disease",
    abstract = "In discriminating benign and malignant origins of cytologically suspicious effusion smears a panel of antibodies against carcinoembryonic antigen (CEA), Fibronectin (F) and MOC-31 was used with immunocytochemical techniques. One hundred and thirty seven effusions were studied of which 107 had a malignant and 30 a benign aetiology as determined by clinical and histological examination. Cytologically 24 were diagnosed as benign, 97 as malignant and 14 as suspicious. Staining for F was positive in all effusions of benign and 3 of malignant origin. MOC-31 was positive in 95 (88.8%) of effusions of malignant origin but none of benign origin. Positive CEA was observed in 43% of effusions of malignant origin and in 10 of benign origin. The combination of MOC-31 positivity measured the sensitivity and specificity of the cytological examination in cases where the cytological examination result was suspicious as did F positivity improve the sensitivity for a benign origin of the effusion. Positivity or negativity for CEA is less valuable than the other parameters."
}