@article{3097080, title = "Design and implementation of a multi-PNN structure for discriminating one-month abstinent heroin addicts from healthy controls using the P600 component of ERP signals", author = "Kalatzis, I and Piliouras, K and Ventouras, E and Papageorgiou, CC and and Liappas, IA and Nikolaou, CC and Rabavilas, AD and Cavouras, DD", journal = "Pattern Recognition Letters", year = "2005", volume = "26", number = "11", pages = "1691-1700", publisher = "ELSEVIER SCIENCE BV", issn = "0167-8655", doi = "10.1016/j.patrec.2005.01.012", keywords = "heroin addicts; event-related potentials (ERPs); P600 component; pattern recognition", abstract = "A multi-probabilistic neural network (multi-PNN) classification structure has been designed for distinguishing one-month abstinent heroin addicts from normal controls by means of the Event-Related Potentials’ P600 component, selected at 15 scalp leads, elicited under a Working Memory (WM) test. The multi-PNN structure consisted of 15 optimally designed PNN lead-classifiers feeding an end-stage PNN classifier. The multi-PNN structure classified correctly all subjects. When leads were grouped into compartments, highest accuracies were achieved at the frontal (91.7%) and left temporo-central region (86.1%). Highest single-lead precision (86.1%) was found at the P3, C5 and F3 leads. These findings indicate that cognitive function, as represented by P600 during a WM task and explored by the PNN signal processing techniques, may be involved in short-term abstinent heroin addicts. Additionally, these findings indicate that these techniques may significantly facilitate computer-aided analysis of ERPs. (c) 2005 Elsevier B.V. All rights reserved." }