@article{3097802,
    title = "Hyperglycaemia and insulinopenia in a neonate with cystic fibrosis",
    author = "Siahanidou, T and Mandyla, H and Doudounakis, S and Anagnostakis, D",
    journal = "ACTA PAEDIATRICA SCANDINAVICA",
    year = "2005",
    volume = "94",
    number = "12",
    pages = "1837-1840",
    publisher = "Wiley",
    doi = "10.1080/08035250510040241",
    keywords = "cystic fibrosis; diabetes; glucose intolerance; infant; neonate",
    abstract = "Abnormal glucose tolerance is a frequent late complication of cystic
fibrosis (CF), but the prevalence of CF-related diabetes mellitus (CFRD)
in children less than 10 y old is less than 2%. The youngest child with
CFRD reported to date was 6 mo of age. Insulinopenia is the primary
cause of abnormal glucose tolerance/CFRD, but it is unknown whether it
may begin in the neonatal period. We describe a case of a neonate with
CF who presented with hyperglycaemia in the diabetic range and marked
insulinopenia. Insulinopenia and impaired glucose tolerance were
permanent findings at 6 and 15 mo of age.
Conclusion: This case suggests that abnormal glucose tolerance/diabetes
may occur much earlier in the course of CF, even during neonatal age.
Careful follow-up and further studies in CF infants could reveal that
the real incidence of glucose intolerance and diabetes in this age group
has been underestimated."
}