@article{3097816,
    title = "Associations between IgG antibody to oral organisms and carotid
intima-medial thickness in community-dwelling adults",
    author = "Beck, JD and Eke, P and Lin, DM and Madianos, P and Couper, D and Moss, and K and Elter, J and Heiss, G and Offenbacher, S",
    journal = "Atherosclerosis",
    year = "2005",
    volume = "183",
    number = "2",
    pages = "342-348",
    publisher = "Elsevier Ireland Ltd",
    issn = "0021-9150",
    doi = "10.1016/j.atherosclerosis.2005.03.017",
    keywords = "antibodies; atherosclerosis; epidemiology; risk factors; periodontal
disease; smoking",
    abstract = "Aims: The aims of this study are to describe the relationships between
IgG antibodies to 17 oral organisms and atherosclerosis as indexed by
carotid intima-medial wall thickness (IMT) and to evaluate the role of
smoking.
Methods and results: Our study is based on a subset of participants in
the Atherosclerosis Risk in Communities (ARIC) Study, who received a
complete periodontal examination during visit 4 (1996-1998). The Outcome
was mean carotid IMT >= 1 mm assessed by B-mode ultrasound. The
exposures were serum IgG antibody levels against 17 periodontal
organisms using a whole bacterial checkerboard immunoblotting technique.
Evaluation of all 17 antibodies indicated that antibody to Campylobacter
rectus resulted in the best-fitting model (OR = 2.3, 95% Cl =
1.83-2.84) and individuals with both high C. rectus and
Peptostreptococcus micros titers had almost twice the prevalence of IMT
>= 1 mm than those with only a high C. rectus antibody (8.3% versus
16.3%). Stratification by smoking indicated that all microbial models
significant for smokers were also significant for never smokers except
for Porphyromonas gingivalis (p = 0.08).
Conclusions: This is the first study to report a relationship between
IgG antibody reactive to oral organisms and subclinical atherosclerosis
with significant relationships evident in both ever and never smokers.
(c) 2005 Elsevier Ireland Ltd. All rights reserved."
}