@article{3101464,
    title = "Maternal hyperthyroidism after intrauterine insemination due to hypertrophic action of human chorionic gonadotropin: A case report",
    author = "Bakas, P. and Tzouma, C. and Creatsa, M. and Boutas, I. and Hassiakos, D.",
    journal = "Clinical and Experimental Obstetrics and Gynecology",
    year = "2016",
    volume = "43",
    number = "3",
    pages = "446-447",
    publisher = "S.O.G. CANADA Inc.",
    doi = "10.12891/ceog2103.2016",
    keywords = "chorionic gonadotropin;  chorionic gonadotropin alpha subunit;  chorionic gonadotropin beta subunit;  follitropin;  liothyronine;  Muellerian inhibiting factor;  oral contraceptive agent;  propylthiouracil;  thyroid hormone;  thyrotropin;  thyroxine;  antithyroid agent;  chorionic gonadotropin, adult;  amniocentesis;  Article;  case report;  controlled ovary stimulation;  drug dose increase;  female;  female infertility;  free liothyronine index;  free thyroxine index;  gonadotropin blood level;  hormone blood level;  human;  hyperthyroidism;  hysteroscopy;  intrauterine insemination;  maternal disease;  meiosis;  multiple pregnancy;  ovary hyperstimulation;  paracentesis;  repeated drug dose;  stimulation;  sweating;  tachycardia;  thyroid function test;  thyroid hormone blood level;  thyrotropin blood level;  twin pregnancy;  weight reduction;  artificial insemination;  hyperthyroidism;  metabolism;  ovulation induction;  pregnancy;  Pregnancy Complications;  procedures;  therapeutic abortion;  treatment failure, Adult;  Antithyroid Agents;  Chorionic Gonadotropin;  Female;  Humans;  Hyperthyroidism;  Insemination, Artificial;  Ovulation Induction;  Pregnancy;  Pregnancy Complications;  Pregnancy Reduction, Multifetal;  Pregnancy, Triplet;  Propylthiouracil;  Treatment Failure",
    abstract = "Purpose of investigation: To report a rare case of maternal hyperthyroidism after intrauterine insemination due to hypertrophic action of hCG. Materials and Methods: A 36-year-old woman after successful intrauterine insemination and triplet pregnancy, developed hyperthyroidism with resistance to medical treatment. Results: All signs of hyperthyroidism resolved and the results of thyroid function tests returned to normal without any medication after embryo meiosis. Conclusions: De novo maternal hyperthyroidism may develop during pregnancy as a result of pathological stimulation of the thyroid gland from the high levels of hCG hormone that can be seen in multiple pregnancies. The risk of hyperthyroidism is related to the number of fetuses. Reversibility of symptomatology can be seen after fetal reduction of multiple pregnancies."
}