@article{3102535,
    title = "Methodological aspects of randomized controlled trials for tinnitus: A systematic review and how a decision support system could overcome barriers",
    author = "Kikidis, D. and Vassou, E. and Schlee, W. and Iliadou, E. and Markatos, N. and Triantafyllou, A. and Langguth, B.",
    journal = "Journal of Clinical Medicine Research",
    year = "2021",
    volume = "10",
    number = "8",
    publisher = "MDPI",
    issn = "1918-3003, 1918-3011",
    doi = "10.3390/jcm10081737",
    keywords = "dexamethasone;  lidocaine;  sulodexide, acupuncture;  adult;  aged;  cognitive behavioral therapy;  counseling;  decision support system;  disease duration;  genetic background;  human;  leisure;  major clinical study;  Medline;  methodology;  mindfulness;  patient health questionnaire;  patient health questionnaire depression;  Preferred Reporting Items for Systematic Reviews and Meta-Analyses;  qigong;  randomized controlled trial (topic);  Review;  socioeconomics;  sound;  sound amplification;  sound therapy;  structured counselling;  systematic review;  tinnitus;  transcranial magnetic stimulation;  treatment outcome",
    abstract = "Although a wide range of tinnitus management interventions is currently under research and a variety of therapeutic interventions have already been applied in clinical practice, no optimal and universal tinnitus treatment has been reached yet. This fact is to some extent a consequence of the high heterogeneity of the methodologies used in tinnitus related clinical studies. In this manu-script, we have identified, summarized, and critically appraised tinnitus-related randomized clinical trials since 2010, aiming at systematically mapping the research conducted in this area. The results of our analysis of the 73 included randomized clinical trials provide important insight on the identification of limitations of previous works, methodological pitfalls or gaps in current knowledge, a prerequisite for the adequate interpretation of current literature and execution of future studies. © 2021 by the authors. Licensee MDPI, Basel, Switzerland."
}